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Cephaloridine, administered parenterally was used for bacterial infections, like lower respiratory tract, skin and urinary tract infections (before 1970s). It is no longer available for therapeutic use.
Cephaloridine acts like other cephalosporin and penicillin antibiotics by interfering with the final step of bacterial cell wall synthesis. As a result the cell wall weakens and cell lysis occurs.
Cephaloridine is more commonly used in veterinary practice to treat mild to severe bacterial infections caused by penicillin resistant and penicillin sensitive bacterial species. 

Drug information on Ceporan (1000mg) (Cephaloridine) from Glaxo SmithKline Pharmaceuticals Ltd.

Ceporan (1000mg)

  Injection
Glaxo SmithKline Pharmaceuticals Ltd.
Generic : Cephaloridine
 57.87
1000mg
1
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Medical Condition(s) for which Ceporan (1000mg) may be prescribed


Overview of Ceporan (1000mg)

• Cephaloridine is a semisynthetic antibiotic with antibacterial activity, derived from the natural antibiotic, cephalosporin C.

Side effects of Ceporan (1000mg)

• Cefaloridine has marked dose-related nephrotoxicity.

• The drug accumulates in the proximal renal tubular cell, probably by active anionic transport.

Probenecid, which blocks such transport, is given to patients to eliminate the nephrotoxicity of cephaloridine when it occurs.


• Other side effects common to first-generation cephalosporin class of antibiotics are

Diarrhea, nausea, rash, pain and inflammation at the injection site


  Gastrointestinal: Pseudomembranous colitis (inflammation of the colon)

  Hematological disorders: Esinophilia, low levels of prothrombin, abnormalities of blood coagulation

  Nephrological disorder: Renal damage at large doses

  Others: Vomiting, headache, dizziness, fungal infections of the mouth and vagina, fever


• Certain complications that maybe caused by the use of cephaloridine include seizures, coma, chronic renal failure, acute renal failure and death.

Dosage & When it is to be taken (Indications)

• The recommended dose for cephaloridine is a daily dose of 1 to 3 g.
• Doses more than 4 g can prove to be nephrotoxic to the patients.

How to use Ceporan (1000mg)?

• Cephaloridine should be taken via intrathecal for the duration of 24 hours and via intramuscular for the duration of 12 hours.

When is Ceporan (1000mg) not to be taken? (Contraindications)

• Cephaloridine is contraindicated in patients with a history of severe allergic reactions to penicillin and cephalosporin antibiotics.
Alcohol should be avoided when taking cephaloridine.

Warnings and Precautions for Ceporan (1000mg)

• A daily dose of more than 4 g of cephaloridine may be toxic to the kidneys of normal patients.
• Smaller doses may damage the kidneys of patients with underlying renal disease or those receiving other nephrotoxic drugs.
• Hence patients with any known renal impairment should be monitored closely.
• Cephaloridine should not be used in patients with high levels of urea and creatinine.

Other Precautions for Ceporan (1000mg)

• The entire course of this antibiotic should be completed even if the patients feel better; this will make sure the infection is cured.
• There have been instances of renal tubular necrosis with uremia and death after large doses in some patients with progressive renal disease, and toxic effects on the central nervous system after intrathecal administration.

Drug Interactions of Ceporan (1000mg)

• Cephaloridine interacts with amikacin (sulfate), ethacrynic acid, frusemide or furosemide, penicillamine, reviparin sodium and anticoagulants like acenocoumarol, dicoumarol, phenindione and phenprocoumon.

Storage Conditions for Ceporan (1000mg)

• The drug should be stored at 2-8°C temperature away from moisture and direct sunlight.



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