Ceftriaxone is an antibiotic, used for the treatment of various infections.
â€¢ Central Nervous System: Dizziness, Headache.
â€¢ Gastrointestinal: Diarrhea, nausea and vomiting.
â€¢ Blood: High concentration of eosinophils, platelet counts in the blood, decrease in white blood cells, low prothrombin levels, bleeding.
â€¢ Lab tests: Increase in liver enzyme, elevated BUN (Blood urea, nitrogen).
â€¢ Local: Indurations/tightness/warmth.
â€¢ Genitourinary: Vaginal inflammation.
â€¢ Miscellaneous: Fatal ceftriaxone-calcium precipitates in lung and kidneys of neonates.
Middle ear infection: Children - IM A single dose of 50 mg/kg (max, 1 gram) is recommended.
Meningitis in children: Children - IV: Recommended initial dose is 100 mg/kg (max, 4 gram), followed by 100 mg/kg/day (max, 4 gram/day) for 7 to 14 days.
Skin or Skin Structure Infections: Children - IV/IM: Recommended daily dosage is 50 to 75 mg/kg once a day or in equally divided doses twice daily (max, 2 gram/day).
Surgical Prophylaxis: Adults - IV: 1 gram as a single dose 30 min to 2 hours before surgery.
Uncomplicated Gonococcal Infections: Adults - IM: 250 mg as single dose.
Miscellaneous Infections: Adults - IV: Usual adult daily dosage is 1 to 2 g once a day or in equally divided doses twice daily, depending on the type and severity of infection (max, 4 gram/day).
Children- IV: Recommended daily dose is 50 to 75 mg/kg IV once a day or in divided doses every 12 h (max, 2 gram/day). IV/IM: Recommended daily dose is 50 to 75 mg/kg IV/IM in divided doses every 12 h (max, 2 gram/day).
Acute Bacterial Otitis Media Persistent/Treatment Failure: Children - IM/IV 50 mg/kg/ IM or IV (not to exceed 1 gram) daily for 3 days.
Pelvic Inflammatory Disease (mild to moderate): Adults - IM 250 mg given IM as a single dose with doxycycline 100 mg orally twice daily for 14 days, with or without metronidazole 500 mg orally twice daily for 14 days.
Uncomplicated Gonococcal Infections: Adults - IM 125 mg given IM as a single dose.
Typhoid:Adult- IV: 4gm/day for 2 days, followed by 2g/day. Child- 75mg/day for 2 days.
It should be given by intravenous route only over around 30 minutes.
The usual Adult Dose is 1 g to 2 g once a day or in equally divided doses twice a day.
The total dose should not exceed 4 grams.
Patients with liver and kidney problems should not receive more than 2 grams per day of ceftriaxone.
Ceftriaxone should not be used by patients with allergy to ceftriaxone or other cephalosporin class antibacterials, penicillins, or other beta-lactam antibacterials
â€¢ Ceftriaxone may cause allergic reactions. Cross-allergies may occur in up to 10% of patients with a history of penicillin allergy. Discontinue the drug in this case.
â€¢ The drug may cause Clostridium difficile-associated diarrhea
â€¢ Avoid excess dosage
Caution is needed in patients with:
â€¢ Hemolytic anemia
â€¢ Kidney problems
â€¢ Liver problems
Do not take Ceftriaxone with:
â€¢ Calcium-containing products
Injection: Store below 25Â°C. Store it at room temperature and keep away from children.
Subscribe to our Free Newsletters!