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Drug information on Hepa-Pro (Ademetionine) from British Biologicals


  Oral Powder
British Biologicals
Generic : Ademetionine
12g / 2.41g / 6g / 50mg / 200mg / 75g / 1900IU / 11IU / 30mcg / 150IU / 50mg / 150mcg / 1.2mg / 1.28mg / 1.6mg / 4.48mcg / 15mg / 4mg / 100mcg / 350mg / 380mg / 150mg / 370mg / 140mg / 108mg / 5mg / 4.48mg / 0.6mg / 1.2mg / 58mcg / 35mcg / 200mg / 1.26g / 1.26g / 100g
200 g
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Drug Name : Ademetionine

Ademetionine is used for treating chronic liver disease such as intrahepatic cholestasis, a condition related to reduced bile flow resulting in accumulation. It is also used to treat mood disorders such as depression, osteoarthritis, and muscle pain or fibromyalgia.
More Info about Ademetionine

Other Trade Names for Ademetionine

Pallavi Singh
Written & Compiled by Pharmacist Pallavi Singh, M. Pharmacy (Pharmacy Practice)
Dr. Simi Paknikar
Medically Reviewed by Dr. Simi Paknikar, MD
Last Updated on Oct 12, 2017

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Medical Condition(s) for which Hepa-Pro may be prescribed

Overview of Hepa-Pro

Ademetionine is also is called as S-adenosylmethionine.

Side effects of Hepa-Pro

  Gastrointestinal disorders: Vomiting, gas, constipation, diarrhea, loss of appetite, dry mouth

  Nervous system disorders: Headache, insomnia, dizziness, nervousness

  Serotonin syndrome: Symptoms include confusion, anxiety, tremors, diarrhea, high blood pressure and seizures

  Others: Sweating, skin rashes, allergic reaction which could include anaphylactic reaction

Dosage & When it is to be taken (Indications)

• Oral: 400-1600 mg per day
• IM/IV: 200-400 mg/day

• Oral: 200 mg thrice daily
• IV: 400 mg/day

Liver Disease, Alcohol Related
• Oral: 1200-1600 mg per day; should not be administered for more than 2 years
• IV: 200-2000 mg/day for 15-30 days
• IM: 200 mg/day for 30 days

Intrahepatic Cholestasis
• Oral: 800 mg twice a day

• 800 mg per day

How to use Hepa-Pro?

• Ademetionine tablets should be swallowed whole.
• For better absorption of ademetionine and complete therapeutic effect, ademetionine tablets should not be taken with meals.

When is Hepa-Pro not to be taken? (Contraindications)

• Ademetionine is contraindicated in patients with bipolar depression because of reports of increased anxiety and mania.
• It should also not be used in patients allergic to the drug.

Warnings and Precautions for Hepa-Pro

• Caution is advised in patients with kidney disease.
• Its use should be avoided in pregnancy especially in the first trimester; should be used only on the advice of a health care provider.
• It should also be avoided during breastfeeding.

Other Precautions for Hepa-Pro

• Ademetionine should be used under the supervision of a physician.
• Folate and vitamin b12 deficiencies may decrease ademetionine levels; therefore patients at risk of these deficiencies should routinely check their vitamin B12 and folic acid level while taking ademetionine.
• Ademetionine should not be used in children and should be stopped at least two weeks before surgery.
• Ammonia levels should be monitored in patients with liver disease taking the medication.

Drug Interactions of Hepa-Pro

• Ademetionine can precipitate serotonin syndrome when administered with antidepressant drugs like fluoxetine, sertraline and clomipramine, monoamine oxidase inhibitors like phenelzine and tranylcypromine, and supplements like St.John's wort.
• It should not be used in patients taking antidiabetes medication since it cause a severe reduction in blood sugar levels.

Storage Conditions for Hepa-Pro

• Store at temperatures not exceeding 30°C.

Disclaimer : updates the prices regularly, however despite that there may be discrepancies in the prices displayed. This can be due to many reasons including -
  • Difference in GST/local taxes
  • Change in price by the company
  • Updation of information may not have happened at the right time
For the above reasons Medindia cannot be held liable for any action taken based on the information provided by its website. The purpose of this website is to only provide the initial guidance and it does not intend to replace professional medical opinion in any manner whatsoever.

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