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Drug information on Hepa-Pro (Ademetionine) from British Biologicals


  Oral Powder
British Biologicals
Generic : Ademetionine
12g / 2.41g / 6g / 50mg / 200mg / 75g / 1900IU / 11IU / 30mcg / 150IU / 50mg / 150mcg / 1.2mg / 1.28mg / 1.6mg / 4.48mcg / 15mg / 4mg / 100mcg / 350mg / 380mg / 150mg / 370mg / 140mg / 108mg / 5mg / 4.48mg / 0.6mg / 1.2mg / 58mcg / 35mcg / 200mg / 1.26g / 1.26g / 100g
200 g
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Medical Condition(s) for which Hepa-Pro may be prescribed

Overview of Hepa-Pro

Ademetionine is also is called as S-adenosylmethionine.

Side effects of Hepa-Pro

  Gastrointestinal disorders: Vomiting, gas, constipation, diarrhea, loss of appetite, dry mouth

  Nervous system disorders: Headache, insomnia, dizziness, nervousness

  Serotonin syndrome: Symptoms include confusion, anxiety, tremors, diarrhea, high blood pressure and seizures

  Others: Sweating, skin rashes, allergic reaction which could include anaphylactic reaction

Dosage & When it is to be taken (Indications)

• Oral: 400-1600 mg per day
• IM/IV: 200-400 mg/day

• Oral: 200 mg thrice daily
• IV: 400 mg/day

Liver Disease, Alcohol Related
• Oral: 1200-1600 mg per day; should not be administered for more than 2 years
• IV: 200-2000 mg/day for 15-30 days
• IM: 200 mg/day for 30 days

Intrahepatic Cholestasis
• Oral: 800 mg twice a day

• 800 mg per day

How to use Hepa-Pro?

• Ademetionine tablets should be swallowed whole.
• For better absorption of ademetionine and complete therapeutic effect, ademetionine tablets should not be taken with meals.

When is Hepa-Pro not to be taken? (Contraindications)

• Ademetionine is contraindicated in patients with bipolar depression because of reports of increased anxiety and mania.
• It should also not be used in patients allergic to the drug.

Warnings and Precautions for Hepa-Pro

• Caution is advised in patients with kidney disease.
• Its use should be avoided in pregnancy especially in the first trimester; should be used only on the advice of a health care provider.
• It should also be avoided during breastfeeding.

Other Precautions for Hepa-Pro

• Ademetionine should be used under the supervision of a physician.
• Folate and vitamin b12 deficiencies may decrease ademetionine levels; therefore patients at risk of these deficiencies should routinely check their vitamin B12 and folic acid level while taking ademetionine.
• Ademetionine should not be used in children and should be stopped at least two weeks before surgery.
• Ammonia levels should be monitored in patients with liver disease taking the medication.

Drug Interactions of Hepa-Pro

• Ademetionine can precipitate serotonin syndrome when administered with antidepressant drugs like fluoxetine, sertraline and clomipramine, monoamine oxidase inhibitors like phenelzine and tranylcypromine, and supplements like St.John's wort.
• It should not be used in patients taking antidiabetes medication since it cause a severe reduction in blood sugar levels.

Storage Conditions for Hepa-Pro

• Store at temperatures not exceeding 30°C.

Disclaimer : The Price of the drugs indicated above may not match the actual price at which they are sold. Prices can change depending on many factors, including GST. These are only approximate indicative prices of the drug.
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