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Drug information on Acitrin (Acitretin) from IPCA Laboratories Ltd.

Acitrin   Capsule IPCA Laboratories Ltd. Generic : Acitretin	350.00 10mg 10 Capsules

Psoriasis

Hypervitaminosis A syndrome (Excess intake of Vitamin A).

•  Heart: Heart attack, clots in blood vessels and stroke.

•  Central Nervous System: Headache, shakiness, sleeplessness, aggressive feelings and/or suicidal thoughts and depression.

•  Gastrointestinal: Dry mouth, increased thirst, taste changes, nausea, vomiting, inflammation of the pancreas and lower stomach pain.

•  Skin: Rash, sweating, itching, scaling, dryness, thinning, dry or chapped lips, damage of skin, abnormal skin odor, hair loss and nail damage.

•  Genitourinary: Vulvo-vaginal infection due to fungal infection.

•  Hypersensitivity: Allergic reaction includes: rash, itching/swelling (especially of the face/tongue/throat), dizziness and trouble in breathing.

•  Miscellaneous: Fever, chills, dark urine and peeling of skin.

•  Potentially Fatal: Sunburn, jaundice and liver toxicity.

Adult: PO- The recommended dose is 25 to 50 mg per day, given as a single dose with the main meal.

It comes as a capsule to take by mouth. It is usually taken once a day with the main meal.

Contraindicated in patients with liver, kidney impairment, during pregnancy (before the start, during and at least 2-3 yr after cessation of therapy), lactation, increased level of lipids in blood.

• It may cause drowsiness or vision changes. Do not drive a car or operate machinery while taking this medication.

• Acitretin is noted for the possibility of severe birth defects and should not be used by pregnant women or women planning to get pregnant within 3 years following the use of this medication.

• Sexually active women of childbearing age who use Acitretin should also use at least 2 forms of birth control concurrently.

• Avoid blood donation during therapy or at least 1-3 years after stopping therapy.

• It may make your skin sensitive to light, so avoid sunlight.

• Remove contact lenses while using this medication otherwise it will increase irritation.

• Monitor liver function, plasma lipid and glucose levels (especially in diabetic patients) regularly.

•

Avoid alcohol consumption while taking this medication.
Do not double the dose to catch up missed dosage.

Store between 15° and 25°C (59° and 77°F) in an airtight container. Protect from light. Avoid exposure to high temperatures and humidity after the bottle is opened. Keep away from children.