This medication is a chemotherapy agent, prescribed for certain types of cancer such as leukemia, Hodgkin disease, and non-Hodgkin lymphomas. It slows or stops the growth of cancer cells in the body.
Contraindicated in patients with demyelinating form of Charcot-Marie-Tooth syndrome (an inherited disorder of nerves).
Adult- PO- The recommended dose is 1.4-1.5 mg/m2 once weekly. Max: 2 mg/week.
It comes as a solution for injection to be administered by a healthcare provider into the vein.
• Caution should be exercised in patients with history of infection, decrease in blood counts, blood problems due to chemotherapy, liver disease, muscle problems, nerve disease, any allergy, during pregnancy and breastfeeding.
• It may cause dizziness or lightheadedness, do not drive a car or operate machinery while taking this medication.
• Most Common :
• Gastrointestinal : Constipation, abdominal cramps, weight loss, nausea, vomiting, mouth ulceration, diarrhea, intestinal necrosis and loss of appetite.
• Genitourinary : Painful urination, bed-wetting and increased urination.
• Heart : High/low blood pressure and heart attack.
• Blood : Bone marrow depression.
• Miscellaneous : Fever and headache.
Avoid excess dosage.
Store it in refrigerator (2°-8°C), protect from light.
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