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Valproic Acid - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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Information about Valproic Acid

Generic Name : Valproic Acid
Pronunciation : val- proe'- ik
Latest prescription information about Valproic Acid. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y46.5 | Therapeutic Classification : Anticonvulsants

Why is Valproic Acid Prescribed? (Indications)

This medication is an anticonvulsant, prescribed for epilepsy, bipolar disorder, and rarely for depression. It works by increasing the amount of a certain chemical in the brain.


When should Valproic Acid not be taken? (Contraindications)

Contraindicated in patients with known urea cycle disorders and hypersensitivity.

What is the dosage of Valproic Acid?

PO- The initial recommended dose is 15 mg/kg/day. The dosage should be increased by 5 to 10 mg/kg/week.

How should Valproic Acid be taken?

It comes as a tablet, capsule, and liquid to take by mouth, with or without food.

What are the warnings and precautions for Valproic Acid?

• Caution should be exercised in patients with history of urea cycle disorder, vomiting, tiredness, irritability, confusion, loss of ability to think, coma, mental retardation, human immunodeficiency virus (HIV), increased blood cholesterol, kidney disease, any allergy, during pregnancy and breastfeeding.

It may cause dizziness, drowsiness or vision changes, do not drive a car or operate machinery while taking this medication.

Avoid alcohol consumption.

Patient may develop with increased risk of suicidal thoughts; watch them carefully.

It may affect platelet counts; avoid injury or bruising.

What are the side effects of Valproic Acid?

   Body as a Whole : Headache, weakness and fever.
   Gastrointestinal : Nausea, vomiting, abdominal pain, diarrhea, loss of appetite, indigestion, heartburn and constipation.
   Central Nervous System : Drowsiness, tremor, dizziness, blurred vision, incoordination, night blindness, emotional lability, abnormal thinking and memory loss.
   Musculoskeletal : Muscle pain/twitching, joint pain and leg cramps.
   Miscellaneous : Flu syndrome, infection, lung inflammation, runny nose, hair loss and weight loss.

What are the other precautions for Valproic Acid?

Avoid excess dosage.

What are the storage conditions for Valproic Acid?

Store it at room temperature.

Learn more about Valproic Acid's interaction with Alcohol

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Vinoy_Kumar, India

Hi, Any solution to 'Drowsiness, tremor, dizziness' side effects because of Valproic Acid(Valprid CR 300)?
I mean any medicine like Vitamin which can suppress it a bit...Thanks.

Deepak, India

Doctor has prescribed VALANCE OD 500 mg to be taken once daily. The patient cannot take the tablet as a whole hence it is crushed & mixed with water & given.Any issues

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