Uridine triacetate an agent that protects from harmful effects of chemotherapy and is called a chemo protectant. It is used for the emergency treatment of adults and children after an overdose of anti-cancer medication. It is also used to treat hereditary orotic aciduria.
Uridine triacetate an agent that protects from harmful effects of chemotherapy and is called a chemo protectant.
It is also used to treat hereditary orotic aciduria. Orotic aciduria is an autosomal recessive disorder caused by an enzyme deficiency resulting in a decreased ability to synthesize pyrimidines.
In orotic aciduria, there is an excessive excretion of orotic acid in urine because of the inability to convert orotic acid to UMP.
It causes megaloblastic anemia and may be associated with mental and physical developmental delays.
Uridine triacetate granules are used both for adult and children. It is generally used for the emergency treatment of the side effects within 4 days or 96 hours following the administration of florouracil or capecitabine (anticancer) drugs.
As it protects against harmful effects of fluorouracil or capecitabine, it is used to protect side effects on the heart or brain from the drug.
Uridine should not be used in patients-
• If there is an allergy or hypersensitivity to uridine.
• Pregnant and breastfeeding women.
• Not recommended for the non-emergent treatment of side effects associated with fluorouracil or capecitabine because it may decrease the effectiveness of these drugs.
• Should not be given after 4 days or 96hrs of administration of fluorouracil or capecitabine.
Uridine triacetate is available as granules in 10-gram packets to be taken by mouth (orally).
For Adults, the dose is 1 packet to be given by mouth every 6 hours for 20 doses, with or without food.
For children, the dose is 6.2 grams/m2 of body surface area given every 6 hours for 20 doses, with or without food.
If you miss a dose of uridine triacetate, the missed dose should be taken as soon as possible. Then take the next dose at a regularly scheduled time.
Mix each packet of uridine granules with 4 ounces or 100 ml of soft food such as applesauce, pudding or yogurt in a small container.
Crush the contents of one full 10-gram packet of granules to a fine powder. Add the crushed granules to 4 ounces (100 mL) of the starch-based thickening product.
Prepare the mixture at a ratio of no greater than 1 gram per 10 mL of reconstituted food while giving to pediatric patients receiving less than 10 grams.
Take this within 30 minutes of mixing.
At least 4 ounces of water should be taken to make sure that patient swallow all of the medicine.
In children, the dose should be given based on their weight.
In case of vomiting, take another full dose as soon as possible and then the next dose at a regular scheduled time.
The dose should be measured using either a scale accurate to at least 0.1 gram, or a graduated teaspoon accurate to ¼ teaspoon.
Administer full course which is 20 doses as directed by the doctor.
It can be given through a nasogastric tube or gastrostomy tube when necessary in case of severe inflammation of the mouth (mucositis) or if the patient is in a coma.
• The dose should not be more than 10grams.
• Do not chew the granules.
• Granules left in the open packet for subsequent dosing should not be used.
• Gastrointestinal: Vomiting, nausea, diarrhea
Pregnant, breastfeeding women and patients aged above 65years are advised to take these granules as per the doctor’s suggestion.
It may interact with digoxin.
Uridine granules must be stored at room temperature 25°C (77°F)
Should be protected from direct sunlight.
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