Information about Triclabendazole

Generic Name : Triclabendazole
Up-to-date prescription details regarding Triclabendazole are provided here.

Pronunciation : Tri-cla-ben-da-zole

Learn the correct pronunciation of the Triclabendazole, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.

You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.

Therapeutic Classification : Antihelmintics

Trade Names/Brand Names of Triclabendazole

India :

Tricloben

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Overview of Triclabendazole

Triclabendazole is an anthelmintic used mainly for the treatment of fascioliasis, a parasitic infection caused by the liver fluke. It is used for treating fascioliasis in humans since 1986. In 1997, after the success of clinical trials for treating fascioliasis and paragonimiasis, the WHO recommended it should be placed on the Essential Drugs List. But the U.S. Food and Drug Administration (FDA) has not approved it's use in humans at that time, although it is registered in some countries where fascioliasis is endemic. In February 2019, it was approved by the US FDA to treat human fascioliasis.

Why is Triclabendazole Prescribed? (Indications)

Triclabendazole is an anthelmintic and the drug of choice recommended by the World Health Organization for the treatment of fascioliasis (a parasitic worm infection caused by the common liver flukes Fasciola hepatica and Fasciola gigantica.

It is a benzimidazole compound that is active against immature and adult Fasciola parasites.

It is also used to treat another food-borne parasitic infection known as paragonimiasis caused by the lung fluke, most commonly Paragonimus westermani.

Triclabendazole is widely used only in developing countries and is not directly approved by the FDA for use in the US. It can be distributed in the US through a special arrangement with the FDA and the manufacturer on an individual patient approval basis.

When should Triclabendazole not be taken? (Contraindications)

Triclabendazole is contraindicated if the patient is allergic to the drug.

What is the dosage of Triclabendazole?

• The recommended dose for the drug is based on the patient’s weight. Typically a dose of 10 mg of triclabendazole per kilogram of body weight is administered (10 mg/kg).

• Patients with severe or heavy Fasciola infections (many parasites) or who did not respond to the single-dose therapy of 10 mg/kg can be given a a total dose of 20 mg/kg.

• The doses are applicable in adult and pediatric populations.

How should Triclabendazole be taken?

• Triclabendazole should be taken orally, one time a day, with food, to improve absorption.

• In the case of a two-dose or a double-dose treatment, the patient is given 2 individual doses of 10 mg/kg, separated in time by 12 to 24 hours so that they receive a total dose of 20 mg/kg.

What are the warnings and precautions for Triclabendazole?

•Use with caution in pregnant women as the drug has not been well studied in the population.

What are the side effects of Triclabendazole?

Triclabendazole is generally considered a safe drug.

Adverse events (AEs) that sometimes occur following treatment can either be systemic (due to biological substances released by the dying worms) or mechanical (due to the expulsion of dead worms from the biliary system towards the intestinal lumen).

Systemic: Mild/transient dizziness, headache, nausea, and urticaria

Mechanical effects: Biliary colic pain, maybe with jaundice.