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Trastuzumab with Hyaluronidase - Indications, Dosage, Side Effects and Precautions

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General Information on Trastuzumab with Hyaluronidase

Generic Name : Trastuzumab with Hyaluronidase
Pronunciation : Tras·tuzum·ab
Latest prescription information about Trastuzumab with Hyaluronidase. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, warnings and its storage instructions . Also listed are the Indian trade name(s) of the drug and its price list.
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Trade Names/Brand Names of Trastuzumab with Hyaluronidase

Herceptin Hylecta- It is a combination of trastuzumab and hyaluronidase.
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Overview of Trastuzumab with Hyaluronidase

Trastuzumab and hyaluronidase combination is indicated for the treatment of breast cancer.

Why is Trastuzumab with Hyaluronidase Prescribed? (Indications)

Trastuzumab along with hyaluronidase is indicated for the treatment of breast cancer among adults. 

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When should Trastuzumab with Hyaluronidase not be taken? (Contraindications)

1. Pregnancy
2. Breastfeeding
3. Allergy to Trastuzumab

What is the dosage of Trastuzumab with Hyaluronidase?

Trastuzumab is available as injection: In a single vial of injection, 600 mg trastuzumab and 10,000 units hyaluronidase is available.

How should Trastuzumab with Hyaluronidase be taken?

It is administered subcutaneously (into the fatty layer under the skin) for over 2-5 minutes once every three weeks.
In patients with adjuvant breast cancer, Trastuzumab can be given for 52 weeks or until disease recurrence, whichever occurs first. Extending the treatment beyond one year is not recommended.

Missed a Dose?

In case a dose is missed, the next dose should be given as soon as possible and the interval between doses should not be less than 3 weeks.

What are the side effects of Trastuzumab with Hyaluronidase?

• General: Fatigue, Injection site reaction, headache, fever, chills, infection
• Musculoskeletal: Joint pain, muscle pain
• GI: Diarrhea
• Respiratory: Upper respiratory tract infection, cough
• Nervous system: Insomnia (lack of sleep)

What are the other precautions for Trastuzumab with Hyaluronidase?

• The drug can cause heart failure. Monitor cardiac function before and during treatment.
• The drug can cause pulmonary toxicity in the form of anaphylaxis (allergic reaction), angioedema (swelling under the skin), and acute respiratory distress syndrome (accumulation of fluid in lungs, symptom- shortness of breath).
• If taken during pregnancy, Trastuzumab can cause oligohydramnios (volume of amniotic fluid is low), and neonatal death. Effective contraception must be used during treatment and 7 months after the last dose is given.
• Trastuzumab can exacerbate chemotherapy-induced low white cell count.
• Monitor patients for reactions like skin rash, shortness of breath, nausea, dizziness, low blood pressure.

What are the Drug Interactions of Trastuzumab with Hyaluronidase?

Trastuzumab can interact with

• Doxorubicin
• Epirubicin
• Cerubidine,
• Novantrone, etc.

What are the storage conditions for Trastuzumab with Hyaluronidase?

Store Trastuzumab in the refrigerator at 2 to 8 o C. Do not shake or freeze.

Last Updated : 3/11/2021



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