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General Information on Tolvaptan

Generic Name : Tolvaptan

Pronunciation : tol-VAP-tan

Latest prescription information about Tolvaptan. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.

Trade Names/Brand Names of Tolvaptan

India : 

International : 

Samsca

Why is Tolvaptan Prescribed? (Indications)

Tolvaptan is a selective vasopressin V2-receptor antagonist, prescribed for hyponatremia (low blood sodium levels).
It works by increasing fluid excretion from the body.  

When should Tolvaptan not to be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Tolvaptan?

PO- The usual starting dose is 15 mg administered once daily. Increase up 30 mg once daily. Maximum: 60 mg once daily.

How should Tolvaptan be taken?

It comes as a tablet to take by mouth, with or without food.

What are the warnings and precautions for Tolvaptan?

Cautions should be exercised in patients with history of diabetes, kidney disease, liver disease, use/abuse of alcohol, who are taking other medications, any allergy, during pregnancy and breastfeeding.

Avoid becoming dehydrated; drink adequate fluids.

It may raise blood sugar level; if it is so consult with your doctor.

Patient may develop with increased risk of Osmotic demyelination syndrome.

What are the side effects of Tolvaptan?

   Most Common : Increased thirst, dry mouth, weakness, constipation, increased urination and increased blood sugar.
   Blood : Blood clot events.
   Heart : Severely abnormal heart rhythm, prolonged prothrombin time.
   Gastrointestinal : Intestinal inflammation.
   Metabolic : Diabetic ketoacidosis.
   Musculoskeletal : Rhabdomyolysis.
   Central Nervous System : Stroke.
   Genitourinary : Urethral bleeding, vaginal bleeding.
   Respiratory : Blood clot in lungs, respiratory failure.
   Vascular disorder : Deep vein thrombosis.

What are the other precautions for Tolvaptan?

Avoid excess dosage.

What are the storage conditions for Tolvaptan?

Store at 25C.

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nandini03, India

can the drug be administered to an eighty five year old? dosage 15mg thrice daily?

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