This medication is an interleukin-6 (IL-6) receptor blocker, prescribed for rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis (SJIA) in 2 year old children either alone or with other medications.
Contraindicated in patients with severe infection, liver impairment, and hypersensitivity.
For Rheumatoid Arthritis-
IV- The recommended starting dose is 4 mg/kg followed by an increase to 8 mg/kg.
For Juvenile Idiopathic Arthritis- IV- The recommended starting dose is 8 mg/kg followed by an increase to 12 mg/kg.
It comes as a solution for injection, to be administered by a healthcare provider into the vein.
Caution should be exercised in patients with history of low blood cells count, hepatitis B, stomach problems, high cholesterol, high blood pressure, diabetes, kidney impairment, cancer, numbness, tingling, GuillainBarrι syndrome, HIV, tuberculosis, who are taking other medications, any allergy, elderly, children, during pregnancy and breastfeeding.
It may cause dizziness, do not drive a car or operate machinery while taking this medication.
Avoid contact with people who have infections that may spread to others.
It may reduce platelet counts; avoid injury or bruising.
Avoid any live vaccination during the treatment period.
Monitor TB, liver function, cholesterol and lipid levels, and complete blood cell counts regularly while taking this medication.
Most Common :
Respiratory tract infections, nasopharyngitis, headache, high blood pressure and increased ALT.
Gastrointestinal : Mouth and gastric ulcer.
Metabolic : Increased weight and bilirubin levels.
Blood : Decrease in white blood cells.
General : Swelling in the extremities.
Respiratory : Difficulty in breathing, cough.
Eye : Eye inflammation.
Genitourinary : Kidney stone.
♦ Miscellaneous: Hypersensitivity Reactions including Anaphylaxis.
Avoid excess dosage.
Store it in refrigerator (2°C to 8°C).