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Temozolomide - Indications, Dosage, Side Effects and Precautions

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Information about Temozolomide

Generic Name : Temozolomide
Pronunciation : TEM-oh-ZOE-loe-mide
Latest prescription information about Temozolomide. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
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Trade Names/Brand Names of Temozolomide

India : 

International : 

Temodar
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Why is Temozolomide Prescribed? (Indications)

This medication is an anticancer agent, used for brain cancers i.e. anaplastic astrocytoma and glioblastoma multiforme. It is also used for treating melanoma.  It slows or stops the growth of cancer cells in the body.

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When should Temozolomide not be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Temozolomide?

Anaplastic astrocytoma: The starting dose is 150 mg/m2 once daily for first 5 days in 28days cycle. It may be adjusted depending upon blood counts. Max: 200 mg/m2/day.
Metastatic melanoma: The dose is given in range of 150 200mg/m2 once daily for first 5 days in 28days cycle, as a single therapy.

How should Temozolomide be taken?

It comes as a capsule to take by mouth, should be taken on an empty stomach.

What are the warnings and precautions for Temozolomide?

• Use a reliable method of birth control to prevent pregnancy. It may harm the fetus.

It may increase your risk of developing a second cancer.Contact your doctor immediately.

Monitor complete blood count, Pneumocystis carinii pneumonia (PCP) development regularly.

Caution should be exercised in patients with history of liver or kidney disease, pregnancy, elderly greater than 70 yrs, children.

It may cause dizziness or drowsiness. Do not drive a car or operate machinery while taking this medication.

What are the side effects of Temozolomide?

  Most common: Hair loss, fatigue, nausea, vomiting, headache, constipation, loss of appetite, convulsions, rash, weakness, diarrhea, weakness, fever, dizziness, abnormal coordination, viral infection, memory loss, and sleeplessness.
  Central Nervous System: Convulsions, dizziness, tingling, drowsiness, incoordination, confusion, anxiety, depression.
  Blood: Decrease in number of all blood cells.
  Endocrine: Adrenal hypercorticism.
  Gastrointestinal : Nausea, vomiting, constipation, diarrhea, abdominal pain, loss of appetite.
  Musculoskeletal : Muscle pain.
  Respiratory: Upper respiratory tract infection, inflammation of pharynx, sinusitis, coughing.
  Skin: Rash, itching.
  Genitourinary: Urinary tract infection, increased frequency.
  Eye: Double vision, vision abnormal.

What are the other precautions for Temozolomide?

Avoid using contaminated solution of this medication.

What are the storage conditions for Temozolomide?

Oral: Store at 15-30C. Store it at room temperature and away from excess heat and moisture.




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