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Last Updated : 11/14/2018

General Information on Talimogene laherparepvec

Generic Name : Talimogene laherparepvec

Pronunciation : tah-LIH-moh-jeen lah-HER-pah-REP-vek

Latest prescription information about Talimogene laherparepvec. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.

Trade Names/Brand Names of Talimogene laherparepvec

Imlygic.

Overview of Talimogene laherparepvec

Talimogene laherparepvec (T-VEC) is a virus (biopharmaceutical drug) to treat melanoma lesions (cancer) which cannot be operated on. It is injected directly into the lesion.

Why is Talimogene laherparepvec Prescribed? (Indications)

Talimogene laherparepvec is an oncolytic (against cancer) virus which is genetically modified to treat non-operable local skin lesions in patients with recurrent melanoma after the initial surgery.  

When should Talimogene laherparepvec not to be taken? (Contraindications)

T-VEC should not be used in patients-
If there is an allergy or hypersensitivity to Talimogene.
Pregnant and breastfeeding women.
Patients with low immunity, leukemia (blood cancer), AIDS or any HIV related illnesses, and those on immunosuppressive therapy. As it is an inactivated herpes virus it can cause life-threatening herpes infection in patients who are having low immunity.

What is the dosage of Talimogene laherparepvec?

T-VEC should be given by injection into skin or into nodal lesions of melanoma that are visible, palpable (easy to touch) or identifiable using ultrasound guidance.
1ml single-use vial contains: 106 plaque-forming units (PFU) per ml as 1st dose up to 4ml can be given for all the lesions and 108 PFU per ml for the subsequent

How should Talimogene laherparepvec be taken?

It should be injected into the lesion in a well-equipped hospital setting by a healthcare professional.
The lesion and surrounding areas should be cleaned with an alcohol swab after which a local anesthetic is injected around the periphery of the lesion. Then, T-VEC is injected into the lesions evenly and completely until the full dose is uniformly dispersed.
After injection, pressure should be applied to the injection site(s) with a sterile gauze for at least 30 seconds. The site should be kept clean and dry.
Patients are advised to cover the injection site for at least a week.

What are the warnings and precautions for Talimogene laherparepvec?

Accidental exposure to T-VEC may lead to herpes infection.

Direct contact with injected lesions, dressings, or body fluids should be avoided.

The contacted area should be cleaned properly if accidental exposure occurs.

Caution is required in case of pregnancy, breastfeeding women, patients with low immunity and patients with autoimmune disorders.

Few patients may develop plasmacytoma(tumor) at the injection site.

What are the side effects of Talimogene laherparepvec?

General: fatigue, chills, fever, nausea , flu-like illness, and pain at the site of injection.

What are the other precautions for Talimogene laherparepvec?

Do not take more than recommended dose which is 4 ml.
Women in the reproductive age group should be advised to use an effective contraception to prevent pregnancy during treatment with T-VEC.
If a pregnant woman was exposed to T-VEC accidentally and if she had active herpes infection, the virus can cross the placental barrier and cause serious side effects in the developing baby.

What are the Drug Interactions of Talimogene laherparepvec?

Acyclovir or other antiherpetic viral agents may change the effectiveness of T-VEC.

What are the storage conditions for Talimogene laherparepvec?

Store T-VEC at −90C to −70C (−130F to −94F).

Last Updated : 11/14/2018
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