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Sorafenib - Indications, Dosage, Side Effects and Precautions

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General Information on Sorafenib

Generic Name : Sorafenib
Pronunciation : soe-RAF-e-nib
Latest prescription information about Sorafenib. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
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Trade Names/Brand Names of Sorafenib

International- Nexavar.
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Why is Sorafenib Prescribed? (Indications)

This medication is a kinase inhibitor, prescribed for renal cell carcinoma (kidney cancer), hepatocellular carcinoma (liver cancer). It decreases tumor growth and replication. 

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When should Sorafenib not be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Sorafenib?

Adult- PO- The recommended dose is 400 mg (two 200 mg tablets) twice daily.

How should Sorafenib be taken?

It comes as a tablet to take by mouth, two times per day on an empty stomach.

What are the warnings and precautions for Sorafenib?

Patient may develop heart attack, bleeding, hypertension, gastrointestinal perforation.

Caution needed for patients with history of high blood pressure, bleeding problems, chest pain, a heart attack, kidney disease other than kidney cancer, or heart or liver disease.

It could cause birth defects, hence both males and females are advised to use contraception while on this medication.

It may reduce the number of clot-forming cells (platelets), avoid situations in which bruising or injury may occur.

What are the side effects of Sorafenib?

  Heart: High blood pressure, reduced blood supply to the heart, heart attack.
  Central Nervous System: Fatigue, sensory nerve disease, weakness, headache, depression.
  Skin: Hair loss, skin disease, rashes, itching, redness, allergy.
  Gastrointestinal: Abdominal pain, diarrhea, loss of appetite, nausea, vomiting, constipation, stomach upset, difficulty in swallowing, mouth ulcer, gastrointestinal perforation.
  Genitourinary: Impotence, kidney failure.
  Blood-Lymphatic: Anemia, decrease in platelets, white blood cells, bleeding.
  Liver: Liver dysfunction.
  Metabolic: Weight loss.
  Musculoskeletal: Joint and/ or muscle pain.
  Respiratory: Difficulty in breathing, hoarseness.
  Miscellaneous: Severe allergic reaction, influenza-like illness, fever.

What are the other precautions for Sorafenib?

If bleeding necessitates medical intervention, consider discontinuation of this medication.

What are the storage conditions for Sorafenib?

Store it at room temperature and in an airtight container. Keep away from children.




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