This medication is a kinase inhibitor, prescribed for renal cell carcinoma (kidney cancer), hepatocellular carcinoma (liver cancer). It decreases tumor growth and replication.
Adult- PO- The recommended dose is 400 mg (two 200 mg tablets) twice daily.
It comes as a tablet to take by mouth, two times per day on an empty stomach.
• Patient may develop heart attack, bleeding, hypertension, gastrointestinal perforation.
• Caution needed for patients with history of high blood pressure, bleeding problems, chest pain, a heart attack, kidney disease other than kidney cancer, or heart or liver disease.
• It could cause birth defects, hence both males and females are advised to use contraception while on this medication.
• It may reduce the number of clot-forming cells (platelets), avoid situations in which bruising or injury may occur.
High blood pressure, reduced blood supply to the heart, heart attack.
• Central Nervous System: Fatigue, sensory nerve disease, weakness, headache, depression.
• Skin: Hair loss, skin disease, rashes, itching, redness, allergy.
• Gastrointestinal: Abdominal pain, diarrhea, loss of appetite, nausea, vomiting, constipation, stomach upset, difficulty in swallowing, mouth ulcer, gastrointestinal perforation.
• Genitourinary: Impotence, kidney failure.
• Blood-Lymphatic: Anemia, decrease in platelets, white blood cells, bleeding.
• Liver: Liver dysfunction.
• Metabolic: Weight loss.
• Musculoskeletal: Joint and/ or muscle pain.
• Respiratory: Difficulty in breathing, hoarseness.
• Miscellaneous: Severe allergic reaction, influenza-like illness, fever.
If bleeding necessitates medical intervention, consider discontinuation of this medication.
Store it at room temperature and in an airtight container. Keep away from children.
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