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Sodium Oxybate - Indications, Dosage, Side Effects and Precautions

Written by Anushta Chandrapalan, M.Sc  | Medically Checked by S. Hemamalini, B. Pharm
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Information about Sodium Oxybate

Generic Name : Sodium Oxybate
Up-to-date prescription details regarding Sodium Oxybate are provided here.
Pronunciation : so-di-um-ox-ih-bate
Learn the correct pronunciation of the Sodium Oxybate, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.
Therapeutic Classification : Central Nervous System Agents

Trade Names/Brand Names of Sodium Oxybate

International- Xyrem.

Why is Sodium Oxybate Prescribed? (Indications)

This medication is a central nervous system depressant, used to treat daytime sleepiness in patients with narcolepsy, and sudden muscular weakness called cataplexy. 

When should Sodium Oxybate not be taken? (Contraindications)

Contraindicated in patients being treated with sedative hypnotic agents, patients with succinic semialdehyde dehydrogenase deficiency, and hypersensitivity.

What is the dosage of Sodium Oxybate?

PO- The recommended starting dose is 4.5 g/night divided into two equal doses of 2.25 gm. The starting dosage can then be increased to a maximum of 9 g/night in increments of 1.5 g/night (0.75 g per dose).

How should Sodium Oxybate be taken?

It comes as an oral solution to take by mouth.

What are the warnings and precautions for Sodium Oxybate?

• It is a habit forming drug. It is called the street drug of abuse. Therefore it is available only through a special program and the treatment can be carried out only under strict monitoring by a doctor.

Avoid drinking alcohol, driving and operating machinery.

Caution should be exercised in patients with history of liver disease, heart disease, high blood pressure, or kidney disease , history of alcohol or drug abuse, asthma, emphysema, or bronchitis, sleep apnea, mental illness such as bipolar disorder or schizophrenia.

What are the side effects of Sodium Oxybate?

  Most Common: Headache, nausea, dizziness, throat pain, drowsiness, vomiting, and urinary incontinence.
  Eye and ENT: Ringing in the ear, blurred vision.
  Gastrointestinal: Abdominal pain, Diarrhea, Indigestion, Nausea and Vomiting.
  General: Lethargy, pain.
  Musculoskeletal: Back pain.
  Central Nervous System: Disturbance in attention, Dizziness, Headache, Confusional state, Depression, Sleep disorder, Sleep walking.

What are the other precautions for Sodium Oxybate?

Avoid excess dosage.

What are the storage conditions for Sodium Oxybate?

Store as per instructions and keep out of reach of children.
Last Updated : August 11, 2022

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dasprem, India


katia, Peru

I have fibromyalgia for over 3 years and I've been living in hell, I really want to give this medication GHS a try.

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