This medication is a potent vasodilator, prescribed for controlling low blood pressure in order to reduce bleeding during surgery. It is also used for high blood pressure.
Contraindicated in patients with compensatory hypertension, patients with known inadequate cerebral circulation, congenital (Leber's) optic atrophy or with tobacco amblyopia, congestive heart failure, and hypersensitivity.
Adult: IV- Hypertensive crisis- For patients not receiving any antihypertensives: Initial: 0.3-1.5 mcg/kg/min, adjust gradually if needed.
Induction of hypotension during anesthesia- Recommended maximum dose is 1.5 mcg/kg/min.
It comes as a solution for injection to be administered by a healthcare provider into the vein.
• Caution should be exercised in patients with under active thyroid, kidney or liver impairment, heart disease, stroke, elderly, lung disease, anemia, dehydration, absence of urination, during pregnancy and breastfeeding.
• Monitor acid-based metabolic problems and avoid excess dosage in order to minimize cyanide accumulation.
• Avoid abrupt withdrawal.
• Serious Effects :
Thiocyanate toxicity, cyanide toxicity and increased intracranial pressure.
• Most Common : Abdominal pain, apprehension, diaphoresis, dizziness, headache, muscle twitching, nausea, palpitations, restlessness and retching.
• Heart : Slow or fast heart rate and electrocardiographic changes.
• Skin : Rash.
• Metabolic : Underactive thyroid.
• Gastrointestinal : Ileus.
• Blood : Decreased platelet aggregation.
• Central Nervous System : Stroke.
• Miscellaneous : Flushing, venous streaking, irritation at the infusion site.
Avoid excess dosage.
Store it at room temperature (20 to 25°C).
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