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General Information on Sodium Nitroprusside

Generic Name : Sodium Nitroprusside

Pronunciation : nye-troe-PRUSS-ide SO-dee-uhm

Latest prescription information about Sodium Nitroprusside. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y52.5 | Therapeutic Classification : Anti- Hypertensives

Trade Names/Brand Names of Sodium Nitroprusside

India : 

International : 

Nitropress, Nipride

Why is Sodium Nitroprusside Prescribed? (Indications)

This medication is a potent vasodilator, prescribed for controlling low blood pressure in order to reduce bleeding during surgery. It is also used for high blood pressure.  

When should Sodium Nitroprusside not to be taken? (Contraindications)

Contraindicated in patients with compensatory hypertension, patients with known inadequate cerebral circulation, congenital (Leber's) optic atrophy or with tobacco amblyopia, congestive heart failure, and hypersensitivity.

What is the dosage of Sodium Nitroprusside?

Adult: IV- Hypertensive crisis- For patients not receiving any antihypertensives: Initial: 0.3-1.5 mcg/kg/min, adjust gradually if needed.
Induction of hypotension during anesthesia- Recommended maximum dose is 1.5 mcg/kg/min.

How should Sodium Nitroprusside be taken?

It comes as a solution for injection to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Sodium Nitroprusside?

Caution should be exercised in patients with under active thyroid, kidney or liver impairment, heart disease, stroke, elderly, lung disease, anemia, dehydration, absence of urination, during pregnancy and breastfeeding.

Monitor acid-based metabolic problems and avoid excess dosage in order to minimize cyanide accumulation.

Avoid abrupt withdrawal.

What are the side effects of Sodium Nitroprusside?

   Serious Effects : Thiocyanate toxicity, cyanide toxicity and increased intracranial pressure.
   Most Common : Abdominal pain, apprehension, diaphoresis, dizziness, headache, muscle twitching, nausea, palpitations, restlessness and retching.
   Heart : Slow or fast heart rate and electrocardiographic changes.
   Skin : Rash.
   Metabolic : Underactive thyroid.
   Gastrointestinal : Ileus.
   Blood : Decreased platelet aggregation.
   Central Nervous System : Stroke.
   Miscellaneous : Flushing, venous streaking, irritation at the infusion site.

What are the other precautions for Sodium Nitroprusside?

Avoid excess dosage.

What are the storage conditions for Sodium Nitroprusside?

Store it at room temperature (20 to 25C).

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