Madhumathi Palaniappan
Written & Compiled by Madhumathi Palaniappan, B.Pharm
Medically Reviewed by The Medindia Medical Review Team on May 31, 2016
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General Information on Silodosin

Generic Name : Silodosin

Pronunciation : sil-OH-doe-sin

Latest prescription information about Silodosin. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : BPH Agents

Trade Names/Brand Names of Silodosin

India : 

International : 

Rapaflo

Why is Silodosin Prescribed? (Indications)

Silodosin is an alpha blocker, prescribed to reduce the symptoms of enlarged prostate (benign prostatic hyperplasia) like incomplete emptying of bladder in men and frequent urination. It works by relaxing muscles in the prostate and bladder neck. 

When should Silodosin not to be taken? (Contraindications)

Silodosin is contraindicated in patients who are allergic to the drug, with severe kidney or liver impairment, and with use of other medicines which inhibit its metabolism e.g., clarithromycin, itraconazole, ketoconazole and ritonavir, or with other alpha blockers like prazosin, terazosin and doxazosin

What is the dosage of Silodosin?

The recommended dose is 8 mg orally once daily with a meal.

How should Silodosin be taken?

It comes as a capsule to take by mouth, with food.

What are the warnings and precautions for Silodosin?

Caution should be exercised in patients with history of low blood pressure, kidney or liver disease, elderly and children.

Avoid driving a car or operating machinery, as it may cause dizziness and lightheadedness.

Get up slowly from bed while taking this medication as silodosin can result in postural hypotension.

Silodosin is prescribed only for men and is not advisable for women especially during pregnancy and breastfeeding.

What are the side effects of Silodosin?

Dry orgasm (problems associated with discharge of semen), dizziness, diarrhea, low blood pressure, headache and nasal congestion.

What are the other precautions for Silodosin?

Avoid excess dosage. Silodosin does not cure the condition as a whole, but provides relief and reduces the symptoms of enlarged prostate.
Do not consume grapefruit juice with silodosin to avoid the dangerous side effects of the drug.
Inform your doctor if you are about to undergo dental or eye surgery while taking silodosin.
Monitor kidney, liver function regularly while taking this medication.

What are the Drug Interactions of Silodosin?

Silodosin should be avoided with:
Beta blockers like atenolol, metaprolol, nebivolol, propranolol, other alpha blockers like doxazosin, prazosin, terazosin, and other drugs used for the treatment of high blood pressure due to its additive effect resulting in low blood pressure.
Gastrointestinal drugs such as cimetidine, cisapride as these drugs mainly interfere with the elimination of silodosin.
Drugs like bosentan stimulate the metabolism of silodosin resulting in reduced levels of the drug.
Drugs used in the treatment of erectile dysfunction like sildenafil, vardenafil and tadalafil as they might severely lower the blood pressure and increase the side effects of the drug causing light headedness, dizziness, headache and nasal congestion.
Protease inhibitors like indinavir, nelfinavir and lopinavir, antibiotics like clarithromycin and erythromycin, and azole antifungals as that of ketoconazole and itraconazole will slow down the metabolic process of silodosin in liver thereby increasing the drug levels in the blood resulting in severe dizziness, fatigue and the person tends to faint.

What are the storage conditions for Silodosin?

Store it in a tightly closed container at room temperature (25C). Protect from excess heat and moisture,Keep out of reach of children.

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vgopal90, India

I have been taking this silodal 8mg since 3 years in morning after breakfast as i misplaced prescription which i found and saw dr advised to take in night, but as i was taking morning same way i am taking in morning, will it cause any problem as i have been frequently having loose stools and stomach pain every week 2 /3 days since 3 months it is more severe despite taking medicine for 1 month for relief by gastroenterologist. My TSH that was within range In Jan 2013 is high now at 11.39 as tested on 21/9, is this due to silodal causing liver problem and affecting my thyroid gland leading to high TSH now, pls share yiur experirnces if any like these adverse ones.

dkanand, India

has it got to be taken life long? can it be stopped after some time say 10 days?

pkchow, India

I am 59 having some problem on urination [urgency, frequency]. My urlologist at Gurgaon prescribed me SILODAL 8mg at bed time. and ROLITEN od. After taking two days my BP went up, felt giddiness and dry throat. Answer to posting of gokul 82 and Razan below: SILODAL (SILOFAST) 4mg is also available in India. Side effect of SILODAL (SILOFAST) includes dry ejaculation (as you feslt).

gokul82, India

My father having a prostate 56 mg . The doctor prescribed the silodal 10 mg medicine. Is the medicine is enough ?

razdan, India

i am having a prostate 47gm and pvr is 199 neither i used to have an urge for urination nor i am getting disturbed during the night. only problem is that the stream of urine is very thin i am afraid someday it may stop so i consulted the doctor, and i was proscribed SILOFAST 8mg and DUTAS. This medcine i am taking for the last ten days. i have observed the desire for sex has gone down and ejaculation is not the same i used to have before taking this medicine 2nd while intercourse it gives me feeling that seamen has come out but while checking not a single down is there. what can be the reason. this all happened within fifteen days.Does this medicine has such effect or there is any other problem. i am 50 years of age with diabetic but sugar level is very much under control. is the operation for prostate must or shall we prolong as i can.Plz advice.

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