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General Information on Selegiline

Generic Name : Selegiline

Pronunciation : se-LE-ji-leen

Latest prescription information about Selegiline. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y46.7 | Therapeutic Classification : Antiparkinson Agents

Trade Names/Brand Names of Selegiline

India : 

International : 

Emsam, Eldepryl, Zelapar

Why is Selegiline Prescribed? (Indications)

This medication is a selective and irreversible monoamine oxidase inhibitor (MAOI), prescribed for Parkinson’s disease either alone or with levodopa as an adjuvant. It prevents the breakdown of dopamine in the brain, thus improving the symptoms of Parkinson’s disease.  

When should Selegiline not to be taken? (Contraindications)

Contraindicated in patients with convulsive disorder, hypersensitivity, active ulceration, pregnancy and breastfeeding.

What is the dosage of Selegiline?

Adult: PO- The recommended dose is 10 mg/day in single or divided doses. Oral disintegrating tablets are taken at a dose of 1.25 to 2.5 mg placed under the tongue.

How should Selegiline be taken?

It comes as a capsule and tablet to take by mouth.

What are the warnings and precautions for Selegiline?

• Caution should be exercised in patients with history of peptic ulcer, uncontrolled high blood pressure, stroke, diabetes, abnormal heart rhythm, chest pain, psychosis, severe liver or kidney dysfunction, during pregnancy and breastfeeding.

• It may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. So get out of bed slowly.

• Do not drive a car or operate machinery while taking this medication.

• Monitor body temperature regularly.

• Reduce levodopa dosage after initiation.

• Avoid alcoholic beverages.

What are the side effects of Selegiline?

  Most Common: Dizziness, nausea, pain, headache, sleeplessness, runny nose, movement disorder, back pain, mouth ulcer, and indigestion.
  Body as a Whole : Allergic reaction, inflammation of skin, face swelling, fever, bruising.
  Central Nervous System : Lack of coordination, depression, dizziness, movement disorder, hallucinations, headache, sleeplessness, drowsiness, tremor, abnormal gait, agitation, emotional lability, increased salivation, nervousness, nerve pain, personality disorder, psychosis, vertigo, migraine.
  Heart: High blood pressure, chest pain, abnormal heart rate and/or rhythm, stroke, congestive heart failure, heart arrest, low blood pressure, heart attack, pallor, syncope.
  Gastrointestinal: Constipation, diarrhea, difficulty in swallowing, indigestion, flatulence, nausea, ulcer of mouth, esophagus or stomach, tooth disorder, vomiting, loss of appetite, gall stone, colitis, gum inflammation, hepatitis.
  Blood: Bruising, abnormal platelet counts, anemia, increased level of white blood cells.
  Metabolic: Low potassium levels, dehydration.
  Musculoskeletal: Leg cramps, muscle/joint pain, tendon rupture, back/neck pain.
  Respiratory : Difficulty in breathing, inflammation of pharynx, sinuses, bronchi, runny nose, asthma, bronchitis, hiccup, nose bleed, lung swelling, pleural effusion, pneumonia, voice alteration.
   Skin: Rash, dry skin, inflammation of skin, fungal infection, itching, skin discoloration, skin ulcer, sweating.
  Genitourinary: Urinary incontinence, urgency or increased frequency.
  Eye and ENT: Abnormal vision, deafness, loss of taste or abnormal taste sensation, ringing in the ear.

What are the other precautions for Selegiline?

Patient may develop with increased risk of melanoma (skin cancer), kidney impairment, exacerbate preexisting movement disorder.

What are the storage conditions for Selegiline?

Oral: Store it at room temperature and in an airtight container. Keep away from excess heat and moisture.

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jeribeviss, India

Hi, very good article. Thanks!

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