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Repaglinide - Indications, Dosage, Side Effects and Precautions

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Information about Repaglinide

Generic Name : Repaglinide
Pronunciation : re-PAG-li-nide
Latest prescription information about Repaglinide. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y42.3 | Therapeutic Classification : Antidiabetics
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Trade Names/Brand Names of Repaglinide

India : 

International : 

Prandin
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Why is Repaglinide Prescribed? (Indications)

This medication is a meglitinide antidiabetic, prescribed for type 2 (non-insulin-dependent) diabetes.  It decreases the amount of glucose by stimulating the pancreas to release insulin.
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When should Repaglinide not be taken? (Contraindications)

Contraindicated in patients with diabetic ketoacidosis, with or without coma, type 1 diabetes, co-administration with gemfibrozil, and known hypersensitivity.

What is the dosage of Repaglinide?

Adults- PO- The recommended initial dose is 0.5 mg with each meal.

How should Repaglinide be taken?

It comes as a tablet to take by mouth, with food.

What are the warnings and precautions for Repaglinide?

• Caution should be exercised in patients with history of adrenal, pituitary, liver, or kidney problems, high blood acid levels, high fever, poor nutrition, alcoholism, severe infection, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.

It may cause dizziness, do not drive a car or operate machinery while taking this medication.

Avoid alcohol consumption.

Monitor fasting blood sugar and hemoglobin A1c level regularly while taking this medication.

What are the side effects of Repaglinide?

   Metabolic : Decrease in blood sugar.
   Respiratory : Upper respiratory tract infection and inflammation of sinus/nose/lungs.
   Gastrointestinal : Nausea, diarrhea, constipation, vomiting, and indigestion.
   Musculoskeletal : Joint pain and back pain.
   Other : Headache, tingling, chest pain, urinary tract infection, tooth disorder and allergy.

What are the other precautions for Repaglinide?

Avoid excess dosage.

What are the storage conditions for Repaglinide?

Store it at controlled room temperature (25C), and in an airtight container.
Learn more about Repaglinide's interaction with Food and Herbs



Repaglinide : Frequently Asked Questions

Q:  Can Repaglinide be used in renal failure?

A: Repaglinide is an effective treatment option for patients with chronic kidney disease and end-stage renal disease. Repaglinide can be used safely in CKD patients without changing the dose(1 Trusted Source
Repaglinide

Go to source
).

Q: Is it safe to take Repaglinide with metformin?

A: Repaglinide and metformin combination increased insulin concentrations. The most common side effect of this combination is hypoglycemia(2 Trusted Source
Effect of combination therapy with repaglinide and metformin hydrochloride on glycemic control in Japanese patients with type 2 diabetes mellitus

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).

Q: Who should not take Repaglinide?

A: Repaglinide is not recommended for patients with diabetic ketoacidosis, type 1 diabetes mellitus, severe liver dysfunction(1 Trusted Source
Repaglinide

Go to source
).

Q: What drug should not be given along with Repaglinide?

A: Due to the increased risk of hypoglycemia, patients taking repaglinide should avoid using drugs like gemfibrozil and clopidogrel(3 Trusted Source
Drug interactions of meglitinide antidiabetics involving CYP enzymes and OATP1B1 transporter

Go to source
).

Q: Is Repaglinide safe during pregnancy?

A: Repaglinide is FDA class C during pregnancy, which means it should be used with caution. There is no evidence to support its safe use during breastfeeding, so an alternative is advised(1 Trusted Source
Repaglinide

Go to source
).

  • 1. Repaglinide - (https://www.ncbi.nlm.nih.gov/books/NBK559305/ )
  • 2. Effect of combination therapy with repaglinide and metformin hydrochloride on glycemic control in Japanese patients with type 2 diabetes mellitus - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025226/ )
  • 3. Drug interactions of meglitinide antidiabetics involving CYP enzymes and OATP1B1 transporter - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116761/ )
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