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Last Updated : 6/18/2018

General Information on Prothionamide

Generic Name : Prothionamide

Pronunciation : Pro-thion-amide

Latest prescription information about Prothionamide. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Anti- Tuberculosis

Other Name(s) of Prothionamide


Overview of Prothionamide

Prothionamide is a thioamide that forms an important component in multidrug-resistant tuberculosis treatment regimens in adults and children.

Why is Prothionamide Prescribed? (Indications)

Prothionamide is prescribed to treat multidrug-resistant tuberculosis (MDR TB) and given as part of a treatment regime, usually involving 5 medicines.

It is also used to treat tuberculous meningitis in adults and children.

Prothionamide is a thioamide, structurally similar to ethionamide and clinically interchangeable with it. 

When should Prothionamide not to be taken? (Contraindications)

Prothionamide is contraindicated in patients with known allergy to the drug.

Prothionamide is also contraindicated in pregnant and lactating women and in patients who have severe renal disease and porphyria.

What is the dosage of Prothionamide?

The recommended dose for prothionamide is

Adults: 15-20 mg/kg/day that amounts to around 500-750 mg per day; maximum dose per day should not exceed 1000 mg or 1 gram
Children: 15-20 mg/kg/day with a maximum daily dose of 1000 mg

How should Prothionamide be taken?

Prothionamide should be taken orally.

Adults and children can take it as one dose to maximize peak levels (particularly for daily doses less than 750 mg) if they can tolerate it.

The dose can be split into two if once a day dose is not tolerated.

Dose may have to be gradually escalated for adults. Increase dose by 250 mg every 3 to 5 days.

Take with or after meals to reduce gastrointestinal adverse effects.

What are the warnings and precautions for Prothionamide?

Complete the entire dose of the drug.

Pyridoxine should be prescribed along with prothionamide (adult doses from 50 to 100 mg daily, up to 50 mg per 250 mg of prothionamide).

What are the side effects of Prothionamide?

  Gastrointestinal:Excessive salivation, metallic taste, nausea, vomiting, abdominal pain, anorexia, diarrhea and inflammation of the mouth
  Central nervous system: Depression, drowsiness, encephalopathy, peripheral neuropathy, headache, restlessness, anxiety, psychotic disturbances
  Liver: Transient increases in Liver Function Test parameters, acute hepatitis (rare)
  Metabolic: Hypothyroidism, gynecomastia, hypoglycemia

What are the other precautions for Prothionamide?

Thyroid function tests have to be taken once in 3 months when taking prothionamide.

Blood sugar levels must be monitored in diabetic patients.

What are the Drug Interactions of Prothionamide?

Prothionamide could cause adverse effects when given along with

Cycloserine (increased risk of neurotoxicity).
Isoniazid (increased serum concentrations).
P-aminosalicylic acid (increased risk of hypothyroidism).
Rifampicin and thiacetazone (increased risk of hepatotoxicity).

What are the storage conditions for Prothionamide?

Prothionamide should be stored at room temperature.

Last Updated : 6/18/2018

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