Information about Procarbazine

Generic Name : Procarbazine
Up-to-date prescription details regarding Procarbazine are provided here.

Pronunciation : proe kar' ba zeen

Learn the correct pronunciation of the Procarbazine, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.

You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.

Trade Names/Brand Names of Procarbazine

India :

Zinocarb | Neozine | Indicarb | P -Carzine | Indicarb (20mg)

More info >>>

International :

Matulane

Why is Procarbazine Prescribed? (Indications)

This medication is an antineoplastic agent, prescribed for Hodgkin disease. It inhibits protein, RNA, and DNA synthesis that help to stop the cancer cell growth.

When should Procarbazine not be taken? (Contraindications)

Contraindicated in patients with bone marrow depression and hypersensitivity.

What is the dosage of Procarbazine?

Adult: The recommended dose is 2–4 mg/kg/day either in a single dose or divided, given for 7 days then increased to 4–6 mg/kg/day.

How should Procarbazine be taken?

It comes as a capsule to take by mouth, with or without food.

What are the warnings and precautions for Procarbazine?

• Caution should be exercised in patients with history of congestive heart failure, adrenal gland tumors (eg, pheochromocytoma), bone marrow depression, heart disease, frequent headaches, mental problems, kidney, or liver disease, any allergy, who are taking other medications, during pregnancy and breastfeeding.

• It may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.

• Avoid exposure to sunlight.

• It may reduce platelet counts, avoid bruising or injury.

What are the side effects of Procarbazine?

Blood - Nose bleed, bruising, anemia and eosinophilia.
Gastrointestinal - Liver dysfunction, jaundice, mouth ulcer, blood vomiting, blood in stool, diarrhea, indigestion, loss of appetite, abdominal pain, constipation and dry mouth.
Central Nervous System - Coma, convulsions, nerve disease, incoordination, tingling, night blindness, diminished reflexes, falling, foot drop, headache, dizziness and unsteadiness.
Heart - Low blood pressure, fast heart rate and fainting.
Eye - Eye bleeding, sensitivity to light, double vision, optic disc swelling and inability to focus.
Respiratory - Lung inflammation/infection and increased cough.
Skin - Skin inflammation, itching, hair loss, pigmentation, rash, hives and flushing.
Allergic reactions - Generalized allergic reactions.
Genitourinary - Blood in urine, urinary frequency, nighttime urination and breast enlargement in male.
Musculoskeletal - Pain, including muscle and joint pain and tremors.
Psychiatric - Hallucinations, depression, apprehension, nervousness, confusion and nightmares.
Miscellaneous - Infections, hearing loss, fever, increased sweating, lethargy, weakness, fatigue, edema, chills, sleeplessness, slurred speech, hoarseness and drowsiness.