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Ponatinib - Indications, Dosage, Side Effects and Precautions

Last Updated on May 11, 2020
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Information about Ponatinib

Generic Name : Ponatinib
Latest prescription information about Ponatinib. Learn its indications, dosage, how to take, when to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.

Trade Names/Brand Names of Ponatinib

International- Iclusig

Why is Ponatinib Prescribed? (Indications)

This medication is a human monoclonal antibody (kinase inhibitor), prescribed for chronic myeloid leukemia (CML). 


What is the dosage of Ponatinib?

PO- The recommended dose is 45mg once daily.

How should Ponatinib be taken?

It comes a tablet to take by mouth, with or without food.

What are the warnings and precautions for Ponatinib?

• Caution should be exercised in patients with history of blood clots, heart, liver or kidney problems, pancreatitis, high blood pressure, bleeding problems, any allergy, who are taking other medications, during pregnancy and breastfeeding.

Monitor complete blood count, patients for fluid retention, heart rhythm, blood pressure, signs and symptoms of heart failure regularly while taking this medication.

Ensure adequate hydration otherwise it may lead to dehydration.

What are the side effects of Ponatinib?

   Most Common : High blood pressure, rash, abdominal pain, fatigue, headache, dry skin, constipation, joint pain, nausea and fever.
   Blood : Anemia, decrease in white blood cells and platelets.
   Miscellaneous : Myelosuppression, abnormal heart rhythm and fluid retention.
   Heart : Heart Failure.
   Gastrointestinal : Constipation, nausea, diarrhea, vomiting, mouth ulcer, GI hemorrhage.
   Infection : Pneumonia, urinary tract infection, upper respiratory tract infection.
   Central Nervous system : Peripheral neuropathy, dizziness.
   Respiratory : Pleural effusion, cough, difficulty in breathing.
   Skin : Rash, dry skin.
   Musculoskeletal : Joint and muscle pain, pain in extremity, back pain, muscle spasms, bone pain.
   General : Weakness.

What are the other precautions for Ponatinib?

Avoid excess dosage.

What are the storage conditions for Ponatinib?

Store it in controlled room temperature (20 to 25C).

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sksamiul, India

Hi, There is a CML patient, in Odisha. He needs "ponatinib" capsule desperately. Can anybody help? Regards Samiul

ManuAdam, India

Sir Thanks for precise info. I have been told that a cheeper substitute of Ponatinib is available in India manufactured by some local company. Is it true? Can you plz provide information about that? My friend in South America is suffering from CML and she has been prescribed Ponatinib. It is a long term treatment and it is costing 10000 dollar per month and it will go on for six months.. She is not so rich to afford it. That is why I am seeking your kind help to know about a cheaper alternative in India or if the same drug procured from India, will it cost less? Please help and provide the info. Thanks M Adam

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