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Piperacillin/Tazobactam - Indications, Dosage, Side Effects and Precautions

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Piperacillin/Tazobactam Medication Information

Learn everything you need to know about Piperacillin/Tazobactam-pronunciation, uses, dosage guidelines, indications, and when to take or avoid it.

Get up-to-date information on side effects, precautions, warnings, and proper storage to ensure safe usage.

Explore Piperacillin/Tazobactam brand names commonly used in India and internationally, along with detailed pricing information. Consult your healthcare provider for tailored medical advice.

Generic Name : Piperacillin/Tazobactam
Pronunciation : PI-per-a-SIL-in/TAZ-oh-BAK-tam
ICD Code : Y40.0 Therapeutic Classification : Antibiotics

Brand Names or Trade Names of Piperacillin/Tazobactam

India :

International :


Zosyn

Why is Piperacillin/Tazobactam Prescribed? (Indications)

This combination medication is an antibacterial agent, prescribed for various infections such as Nosocomial pneumonia. It blocks the bacteria's cell wall growth, which kills the bacteria. Tazobactam inhibits the action of bacterial beta-lactamases. It is added to the extended spectrum beta-lactam antibiotic piperacillin. It broadens the spectrum of piperacillin by making it effective against organisms that express beta-lactamase and would normally degrade piperacillin.

When should Piperacillin/Tazobactam not be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Piperacillin/Tazobactam?

IV- The recommended dose is 3.375 mg 4 times a day, for 7 to 10 days. A higher initial dose of 4.5 mg 4 times a day may be used for more severe infections.

How should Piperacillin/Tazobactam be taken?

It comes as a solution for injection, administered by a healthcare provider.

What are the warnings and precautions for Piperacillin/Tazobactam?

•Caution should be exercised in patients with history of asthma; hay fever; or kidney, liver, or gastrointestinal disease (especially colitis), during pregnancy and breastfeeding.

Repeated electrolyte estimations may be needed especially in patients with low potassium levels.

Monitor blood functions regularly.

What are the side effects of Piperacillin/Tazobactam?

It may lead to increase risk of fever, rashes in patients with cystic fibrosis, bleeding, super infections, convulsions, kidney failure.
Allergic Reactions- Diarrhea, severe allergic reactions, skin rashes, itching, occasionally platelet mediated bleeding, rigors, malaise, inflammation in stomach.
Local- Injection-site reactions such as pain, swelling, redness, indurations and vein inflammation.
Gastrointestinal- Inflammation of stomach, hairy tongue, inflammation of colon, nausea and vomiting, blood in stool.
Genitourinary- Urine retention, painful urination.
Blood- Decrease in white blood cells.
Lab- Increase in liver enzymes, blood urea nitrogen, and presence of red blood cells in urine.
Miscellaneous- Chills, facial swelling, mucosal bleeding, tightness in throat.

What are the other precautions for Piperacillin/Tazobactam?

Continue to use this medication until the full prescribed amount is finished.

What are the storage conditions for Piperacillin/Tazobactam?

Injection vials should be stored at (20-25°C) room temperature prior to reconstitution.

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