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General Information on Pantoprazole

Generic Name : Pantoprazole

Pronunciation : pan toe' pra zole

Latest prescription information about Pantoprazole. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y53.0 | Therapeutic Classification : Antiulcers

Why is Pantoprazole Prescribed? (Indications)

This medication is a proton-pump inhibitor, prescribed for gastroesophageal reflux disease (GERD), ulcers, Zollinger-Ellison Syndrome, and erosive esophagitis. It decreases the amount of acid made in the stomach. 

When should Pantoprazole not to be taken? (Contraindications)

Hypersensitivity and lactation.

What is the dosage of Pantoprazole?

PO- GERD- 20-40 mg /day in the morning for 4 to 8 weeks if needed. Maintenance: 20-40 mg/day.
IV- 40 mg/day for 7 to 10 days.
Erosive esophagitis: Adults 40 mg/day up to 8 weeks.
Children: 20mg/day up to 8weeks.
Zollinger-Ellison Syndrome: 40mg twice daily. IV: 80 mg every 12 hour.

How should Pantoprazole be taken?

It comes as a delayed-release (long-acting) tablet to take by mouth. It is usually taken once or twice a day. It should be taken approximately 30 minutes prior to meals for maximal effectiveness. Tablets should be swallowed whole and should not be crushed, split or chewed. Injection administered by healthcare providers as into the vein.

What are the warnings and precautions for Pantoprazole?

• Long-term therapy may lead to bacterial overgrowth in the GI tract, atrophic gastritis.

• Monitor liver function regularly (if enzymes increase, discontinue) because it may lead to liver damage.

• Caution needed during pregnancy; not recommended in children <18 year.

• Patient may develop with increased risk of Clostridium difficile associated diarrhea (CDAD).

What are the side effects of Pantoprazole?

•  Central Nervous System: Headache, anxiety, weakness, dizziness, muscle tightness, migraine, sleeplessness, damage to the eye nerve, confusion, increased potassium level in blood, speech disorder, tinnitus, uneasiness, fatigue, vertigo.
•  Skin: Rash, severe allergic reactions (eg, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis).
•  Eye and ENT: Inflammation of pharynx, stuffy nose, blurred vision.
•  Gastrointestinal: Nausea, vomiting, diarrhea, pain, constipation, rarely inflammation of pancreas.
•  Genitourinary: Urinary frequency, urinary tract infection, kidney disease, creatinine increased.
•  Blood: Pancytopenia- decrease of all types of blood cells, including red and white blood cells as well as platelets.
•  Liver: Increased liver enzymes, liver cells damage leading to jaundice and liver failure.
•  Local: Injection-site reactions (including abscess, thrombophlebitis).
•  Metabolic: Increase in fat, sugar, cholesterol, weight changes, uric acid in the blood.
•  Musculoskeletal: Joint pain, back pain, neck pain.
•  Respiratory: Asthma, cough, difficulty in breathing, upper respiratory tract infection.
•  Miscellaneous: Chest pain, flu syndrome, infection, severe and life-threatening reaction.

What are the other precautions for Pantoprazole?

It should be taken every day only when symptoms are present.

What are the storage conditions for Pantoprazole?

Store it in room temperature and keep away from children.

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