Information about Pamidronate
Generic Name : PamidronateUp-to-date prescription details regarding Pamidronate are provided here.
Pronunciation : PAM-i-DROE-nate
Learn the correct pronunciation of the Pamidronate, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.
ICD Code : Y57.9 Therapeutic Classification : Bone Enhancers
Trade Names/Brand Names of Pamidronate
India :
Pamidria Inj |
Barobal |
Bonapam Inj |
Pamidria Inj |
Aredia 30 Mg Vial |
Pamidronate Disod 90 Mg Vial |
Bonapam Inj |
Bonapam Inj |
Aredronet® [Vial] |
Aredia 30mg Injection
International :
Aredia
Why is Pamidronate Prescribed? (Indications)
This medication is a bisphosphonate, prescribed for Paget's disease (a condition in which the bones are soft and weak and may be deformed, painful, or easily broken), high blood calcium levels (hypercalcemia) that may occur with cancer or multiple myeloma especially when the bone is affected. It works by slowing bone breakdown, increasing bone density (thickness) and decreasing the amount of calcium released from the bones into the blood.When should Pamidronate not be taken? (Contraindications)
Contraindicated to pregnant women and patients with known hypersensitivity.What is the dosage of Pamidronate?
Adult: IV- Paget's disease of bone- 30 mg/day for 3 consecutive days.Hypercalcemia- 60 to 90mg, as single dose, over 2 to 24 hours.
Multiple Myeloma with bone disease- 90 mg administered as a 4-hour infusion given on a monthly basis.
How should Pamidronate be taken?
It comes as a solution to inject into a vein, administered by a healthcare provider.What are the warnings and precautions for Pamidronate?
•Do not take calcium and vitamin D supplement if you have high blood calcium levels.If possible, avoid dental treatment while you are using this medication to prevent osteonecrosis of the jaw.
• It may increase the risk of heart failure in patients with heart disease.
Inject slowly to reduce risk of adverse effects (e.g. injection site reactions, kidney impairment).
♦Monitor blood counts in patients with preexisting poor blood counts.
What are the side effects of Pamidronate?
- General- Generalized pain, fever, reactivation of viral diseases. Flu-like reaction may occur initially.
- Heart - High blood pressure, abnormal heart rate or rhythm, heart failure, syncope.
- Central Nervous System- Confusion, visual hallucinations, electrolyte imbalance, sleeplessness, nervousness, drowsiness, mental or mood changes.
- Gastrointestinal- Abdominal pain, loss of appetite, constipation, nausea, vomiting, diarrhea, mouth ulcer, gastrointestinal hemorrhage, osteonecrosis of jaw.
- Genitourinary- Increased blood urea, renal tubular disorders (RTD).
- Skin - Rash, itching.
- Eye- Inflammation of eye tissues.
- Blood- Decrease in red blood cells, white blood cells and platelets.
- Metabolic- Low thyroid hormone, decrease in calcium, potassium, magnesium, phosphate level in blood.
- ♦Respiratory- Runny nose, upper respiratory infection, adult respiratory distress syndrome (ARDS and interstitial lung disease (ILD).
- Musculoskeletal- Bone and muscle pain
Rare instances of allergic manifestations have been reported, including low blood pressure, difficulty in breathing, or angioedema, and, very rarely, anaphylactic shock. - Potentially Fatal: Acute kidney and heart failure.
