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Palonosetron - Indications, Dosage, Side Effects and Precautions

Last Updated on May 11, 2020
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Information about Palonosetron

Generic Name : Palonosetron
Pronunciation : PAL-oh-NOE-se-tron
Latest prescription information about Palonosetron. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y43.0 | Therapeutic Classification : Antiemetics
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Trade Names/Brand Names of Palonosetron

India : 

International : 

Aloxi
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Why is Palonosetron Prescribed? (Indications)

This medication is 5-HT3 receptor blocker, prescribed for prevention of chemotherapy-induced nausea and vomiting.  It blocks the action of serotonin, a natural substance that may cause nausea and vomiting.
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When should Palonosetron not be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Palonosetron?

Dosage for Adults IV- A single 0.25 mg dose is administered over 30 seconds.

How should Palonosetron be taken?

It comes as a solution for injection to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Palonosetron?

• Caution should be exercised in patients with history of heart disease, decrease in blood minerals, any allergy, who are taking other medications, children, during pregnancy and breastfeeding.

It may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.

What are the side effects of Palonosetron?

   Most Common : Headache, constipation, diarrhea, dizziness, fatigue, abdominal pain and sleeplessness.
   Heart : Fast heart rate, slow heart rate, low or high blood pressure, abnormal heart rhythm and heart attack.
   Skin : Skin inflammation and rash.
   Eye and ENT : Motion sickness, ringing in the ear, eye irritation and vision abnormality.
   Gastrointestinal : Indigestion, dry mouth, hiccups and flatulence.
   General : Weakness, fever, hot flash and flu-like syndrome.
   Liver : Increase in liver enzymes level.
   Metabolic : Increase in blood minerals and sugar, loss of appetite and acidity.
   Musculoskeletal : Joint pain.
   Central Nervous System : Drowsiness, sedation, tingling, anxiety and emotions.
   Genitourinary : Urinary retention.

What are the other precautions for Palonosetron?

Avoid excess dosage.

What are the storage conditions for Palonosetron?

Store it at controlled temperature (20-25C). Protect from light.



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