Nitisinone Medication Information

Get detailed information on Nitisinone, including pronunciation, uses, dosage guidelines, indications, and instructions on how and when to take it and when to avoid it.

The updated prescription information on Nitisinone provides an overview of possible side effects, precautions, warnings, and storage tips.

You'll also find brand names used in india and internationally, along with pricing details. For further clarification, consult your healthcare provider.

Generic Name : Nitisinone

Pronunciation : nye-TISS-ih-known

ICD Code : Y53.8 Therapeutic Classification : Gastrointestinal Agents

Trade Names/Brand Names of Nitisinone

International :

Orfadin

Why is Nitisinone Prescribed? (Indications)

This medication is a 4-hydroxyphenylpyruvate dioxygenase inhibitor, prescribed for hereditary tyrosinemia type 1 (HT-1) (rare genetic metabolic disorder). It works by blocking the breakdown of tyrosine.

When should Nitisinone not be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Nitisinone?

PO- The recommended dose is 1 to 2 mg/kg divided into two daily doses.

How should Nitisinone be taken?

It comes as a capsule to take by mouth, without food.

What are the warnings and precautions for Nitisinone?

• Caution should be exercised in patients with history of metabolic disorder, any allergy, who are taking other medications, during pregnancy and breastfeeding.

• Follow proper diet program as per your healthcare provider’s advice.

• Monitor sugar level regularly for diabetic patients during the treatment.

• Monitor blood cell counts, vision tests, liver function tests and blood phosphate or tyrosine levels regularly while taking this medication.

What are the side effects of Nitisinone?

Liver- Liver failure/cancer.
Eye - Eye inflammation, clouding of eyes and eye pain.
♦ Blood and lymphatic - Decreased white blood cells and platelets count, bruising, nose bleed and high plasma tyrosine levels.
Skin - Itching, inflammation, dry skin, rash and hair loss.