Information about Nitisinone

Generic Name : Nitisinone
Up-to-date prescription details regarding Nitisinone are provided here.

Pronunciation : nye-TISS-ih-known

Learn the correct pronunciation of the Nitisinone, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.

You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.

ICD Code : Y53.8 Therapeutic Classification : Gastrointestinal Agents

Trade Names/Brand Names of Nitisinone

International :

Orfadin

Why is Nitisinone Prescribed? (Indications)

This medication is a 4-hydroxyphenylpyruvate dioxygenase inhibitor, prescribed for hereditary tyrosinemia type 1 (HT-1) (rare genetic metabolic disorder). It works by blocking the breakdown of tyrosine.

When should Nitisinone not be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Nitisinone?

PO- The recommended dose is 1 to 2 mg/kg divided into two daily doses.

How should Nitisinone be taken?

It comes as a capsule to take by mouth, without food.

What are the warnings and precautions for Nitisinone?

• Caution should be exercised in patients with history of metabolic disorder, any allergy, who are taking other medications, during pregnancy and breastfeeding.

• Follow proper diet program as per your healthcare provider’s advice.

• Monitor sugar level regularly for diabetic patients during the treatment.

• Monitor blood cell counts, vision tests, liver function tests and blood phosphate or tyrosine levels regularly while taking this medication.

What are the side effects of Nitisinone?

Liver- Liver failure/cancer.
Eye - Eye inflammation, clouding of eyes and eye pain.
♦ Blood and lymphatic - Decreased white blood cells and platelets count, bruising, nose bleed and high plasma tyrosine levels.
Skin - Itching, inflammation, dry skin, rash and hair loss.