Natalizumab Medication Information

Discover comprehensive details about Natalizumab, including its pronunciation, uses, dosage instructions, indications, and guidelines on how and when to take it or avoid it.

The updated prescription information covers potential side effects, precautions, warnings, and storage recommendations.

Additionally, explore the Natalizumab brands available in India and internationally, along with pricing information. For personalized advice, consult your healthcare provider.

Generic Name : Natalizumab

Pronunciation : NA-ta-LIZ-oo-mab

ICD Code : Y43.4 Therapeutic Classification : Immunosuppressants

Brand Names or Trade Names of Natalizumab

International :

Tysabri

Why is Natalizumab Prescribed? (Indications)

This medication is a humanized monoclonal antibody, prescribed for multiple sclerosis and Crohn's disease. It stops certain cells of the immune system from reaching the brain and spinal cord or digestive tract and causes damage of those cells.

When should Natalizumab not be taken? (Contraindications)

Contraindicated in patients with progressive multifocal leukoencephalopathy ((PML) (life-threatening infection of the brain)), and hypersensitivity.

What is the dosage of Natalizumab?

IV- The recommended dose is 300 mg, over one hour infusion every four weeks.

How should Natalizumab be taken?

It comes as a solution for injection to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Natalizumab?

• Caution should be exercised in patients with history of liver impairment, poor immunity, fever, herpes, shingles, or an infection, are receiving chemotherapy or radiation treatments, any allergy, who are taking other medications, during pregnancy and breastfeeding.

• It may cause dizziness, do not drive a car or operate machinery while taking this medication.

• Avoid contact with people who have infections.

• Monitor complete blood cell counts, liver function, and magnetic resonance imaging (MRI) scans regularly while taking this medication.

• Regular visit to your doctor’s office is recommended.

What are the side effects of Natalizumab?

Most Common - Headache, fatigue, joint pain, urinary tract infection, lower respiratory tract infection, stomach inflammation, vaginal inflammation, depression, pain in extremity, abdominal discomfort, diarrhea, and rash.
General - Chest discomfort, hypersensitivity reactions, seasonal allergy, rigors and increased or decreased weight.
Genitourinary - Urinary tract infection, Irregular periods, painful menstruation, absence of menstrual cycle and ovarian cyst.
Musculoskeletal - Pain in extremity, muscle cramp and joint swelling.
Gastrointestinal - Abnormal liver function and tooth infections.
Skin - Rash, itching, night sweats and skin inflammation.
Central Nervous System - Depression, drowsiness, fainting, kidney impairment, urinary incontinence and urinary urgency/frequency.
Respiratory - Lower respiratory tract infection.