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Natalizumab - Indications, Dosage, Side Effects and Precautions

Last Updated on Jul 27, 2011
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Information about Natalizumab

Generic Name : Natalizumab
Pronunciation : NA-ta-LIZ-oo-mab
Latest prescription information about Natalizumab. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y43.4 | Therapeutic Classification : Immunosuppressants

Trade Names/Brand Names of Natalizumab

International- Tysabri.

Why is Natalizumab Prescribed? (Indications)

This medication is a humanized monoclonal antibody, prescribed for multiple sclerosis and Crohn's disease. It stops certain cells of the immune system from reaching the brain and spinal cord or digestive tract and causes damage of those cells.


When should Natalizumab not be taken? (Contraindications)

Contraindicated in patients with progressive multifocal leukoencephalopathy ((PML) (life-threatening infection of the brain)), and hypersensitivity.

What is the dosage of Natalizumab?

IV- The recommended dose is 300 mg, over one hour infusion every four weeks.

How should Natalizumab be taken?

It comes as a solution for injection to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Natalizumab?

• Caution should be exercised in patients with history of liver impairment, poor immunity, fever, herpes, shingles, or an infection, are receiving chemotherapy or radiation treatments, any allergy, who are taking other medications, during pregnancy and breastfeeding.

• It may cause dizziness, do not drive a car or operate machinery while taking this medication.

• Avoid contact with people who have infections.

• Monitor complete blood cell counts, liver function, and magnetic resonance imaging (MRI) scans regularly while taking this medication.

• Regular visit to your doctor’s office is recommended.

What are the side effects of Natalizumab?

   Most Common : Headache, fatigue, joint pain, urinary tract infection, lower respiratory tract infection, stomach inflammation, vaginal inflammation, depression, pain in extremity, abdominal discomfort, diarrhea, and rash.
   General : Chest discomfort, hypersensitivity reactions, seasonal allergy, rigors and increased or decreased weight.
   Genitourinary : Urinary tract infection, Irregular periods, painful menstruation, absence of menstrual cycle and ovarian cyst.
   Musculoskeletal : Pain in extremity, muscle cramp and joint swelling.
   Gastrointestinal : Abnormal liver function and tooth infections.
   Skin : Rash, itching, night sweats and skin inflammation.
   Central Nervous System : Depression, drowsiness, fainting, kidney impairment, urinary incontinence and urinary urgency/frequency.
   Respiratory : Lower respiratory tract infection.

What are the other precautions for Natalizumab?

Avoid excess dosage.

What are the storage conditions for Natalizumab?

Store it in refrigerator (2 to 8°C). Do not freeze it.

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