Naloxone - Indications, Dosage, Side Effects and Precautions

Last Updated on August 11, 2022
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Information about Naloxone

Generic Name : Naloxone
Up-to-date prescription details regarding Naloxone are provided here.
Pronunciation : nal-OX-one
Learn the correct pronunciation of the Naloxone, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.
Therapeutic Classification : Opioid Antagonists

Trade Names/Brand Names of Naloxone

India : 

International : 


Why is Naloxone Prescribed? (Indications)

This medication is an opioid antagonist, prescribed for morphine and most other opioid poisoning. It is used to reverse respiratory depression in the newborn when the mother was administered opioids during labor. It is also indicated for the diagnosis of suspected acute opioid over dosage. It may also be useful in other conditions such as to increase blood pressure in certain types of shock, and central nervous system injuries.  

When should Naloxone not be taken? (Contraindications)


What is the dosage of Naloxone?

Adult: Opioid over dosage- The recommended dose is 0.4- to 0.8mg, IV, repeat if needed at 2-3 min intervals. Consider over dosage with other drugs if there is no response after a total of 10 mg has been given.

How should Naloxone be taken?

It is usually given as an injection by a doctor or hospital staff.

What are the warnings and precautions for Naloxone?

• It may make you drowsy. Do not drive a car or operate machineries while taking this medication.

Caution needed for patients physically dependent on opioids, or who have received large doses of opioids (acute withdrawal syndrome may be precipitated), pregnancy and breastfeeding.

What are the side effects of Naloxone?

Adverse effects with naloxone occur when it is given to postoperative patients or due to sudden reversal of opioid depression or sudden withdrawal in opioid dependence.
  Potentially Fatal: Severe cardiopulmonary effects in postoperative patients, most frequently in those with preexisting heart disease.
  Heart: Fluid accumulation in the lungs, cardiac arrest or failure, fast heart rate.
  Gastrointestinal: Vomiting, nausea.
  Central Nervous System: Convulsions, tingling, agitation, hallucination, tremulousness.
  Respiratory : Difficulty in breath, respiratory depression.
  Skin : Injection site reactions, sweating.

What are the other precautions for Naloxone?

Do not change the dosage without your doctor's advice.

What are the storage conditions for Naloxone?

Injection: Store it at room temperature (25C). Protect from light.
Last Updated : August 11, 2022

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