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Nalmefene - Indications, Dosage, Side Effects and Precautions

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Information about Nalmefene

Generic Name : Nalmefene
Pronunciation : NAL-me-feen
Latest prescription information about Nalmefene. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Opiate Antagonist
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Trade Names/Brand Names of Nalmefene

International- Revex.
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Why is Nalmefene Prescribed? (Indications)

This medication is an opioid receptor antagonist, prescribed for partial reversal of opioid drug effects, alcohol abuse and other addictions.  It works by blocking the opiate receptor sites.

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When should Nalmefene not be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Nalmefene?

It is available in two concentrations.
A concentration suitable for postoperative use (100 g/ml) in a blue labeled ampule containing ONE (1) ml and a concentration suitable for the management of overdose (1 mg/ml, 10 times as concentrated, 20 times as much drug) in a green labeled ampule containing TWO (2) ml. Proper steps should be taken to prevent use of the incorrect concentration.
Recommended Doses for Reversal of Postoperative Opioid Depression.
U Management of Known or Suspected Opioid Overdose.
Use 1.0 mg/ml dosage strength (green label).
Use 100 g/ml dosage strength (blue label).
The recommended initial dose for non-opioid dependent patients is 0.5-mg/70 kg. If needed, this may be followed by a second dose of 1.0 mg/70 kg, 2-5 minutes later.

How should Nalmefene be taken?

It comes as a solution for injection to be administered by a healthcare provider into the vein or muscle.

What are the warnings and precautions for Nalmefene?

• Caution should be exercised in patients with history of heart, liver or kidney disease, any allergy, elderly, taking pain relievers for more than 2 weeks, during pregnancy and breastfeeding.

It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.

What are the side effects of Nalmefene?

This medication is generally well tolerated.
  Most Common: Nausea, dizziness, fever, headache, fast heart rate, high blood pressure, chills, muscle aches, abdominal cramps and joint pain.
  Less Frequent:
  Heart: Slow heart rate and abnormal heart rhythm.
  Gastrointestinal: Diarrhea and dry mouth.
  Central Nervous System: Drowsiness, depression, agitation, nervousness, tremor, confusion, withdrawal syndrome and abnormal contraction of muscles.
  Respiratory: Inflammation of pharynx.
  Skin: Itching.
  Genitourinary: Urinary retention.

What are the other precautions for Nalmefene?

Avoid excess dosage.

What are the storage conditions for Nalmefene?

Store it at room temperature (25-30C) and in an airtight container.




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