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General Information on Nabumetone

Generic Name : Nabumetone

Pronunciation : nab-UE-me-tone

Latest prescription information about Nabumetone. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y45.3 | Therapeutic Classification : Analgesics

Trade Names/Brand Names of Nabumetone

India : 

International : 

Relafen

Why is Nabumetone Prescribed? (Indications)

This medication is a nonsteroidal anti-inflammatory agent(NSAIA), used to treat pain and inflammation associated with muscle, bone and joint disorders such as rheumatoid arthritis and osteoarthritis. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

When should Nabumetone not to be taken? (Contraindications)

Active peptic ulceration; severe liver impairment; patients in whom other NSAIDs or aspirin are likely to induce asthma, severe allergic reactions, pregnancy (3rd trimester), nursing mothers, perioperative pain during heart bypass (CABG).

What is the dosage of Nabumetone?

Adult: Oral- 1 g as a single dose in the evening, followed by 0.5-1 g in the morning if needed.

How should Nabumetone be taken?

It comes as a tablet to take by mouth, with or without food.

What are the warnings and precautions for Nabumetone?

Caution should be exercised in patients with history of pre-existing cardiovascular risk factors or disease; fluid retention, high blood pressure, digestive tract ulcers, elderly or debilitated patients, other forms of asthma, liver disease.

It could cause heart attack and stroke especially in patients already at a risk.

Closely monitor patients with any abnormal liver function test, and kidney disease. Withhold for at least 4-6 half-lives prior to surgical or dental procedures.

What are the side effects of Nabumetone?

  Most Common: Diarrhea, dyspepsia, and abdominal pain.
  Gastrointestinal: Gastritis, gastrointestinal ulcers and bleeding, Constipation, flatulence, nausea, , dry mouth, difficulty in swallowing , mouth ulcer, vomiting, altered appetite, liver function abnormalities including liver failure.
  Central Nervous System: Dizziness, headache, fatigue, increased sweating, sleeplessness, nervousness, drowsiness, weakness, agitation, anxiety, confusion, depression, tingling, tremor, fainting.
  Skin: Mild to severe allergic reactions, increased sensitivity to light.
  Heart: Inflammation of blood vessels. It could increase the incidence of heart attack and stroke.
  Respiratory: Difficulty in breathing, lung inflammation.
  Genitourinary: Decrease in kidney function, , kidney failure, vaginal bleeding.
  Eye and ENT: Ringing in the ear, abnormal vision.
  Blood: Decrease in platelets.
  Metabolic: Weight gain.
  Miscellaneous: Swelling of the leg.
  Hypersensitivity: Serious allergic reactions which lead to death.

What are the other precautions for Nabumetone?

Do not take aspirin while using this medication.

What are the storage conditions for Nabumetone?

Oral: Store it at room temperature (20-25C). Store it in an airtight container, and keep away from children.

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