Nabumetone - Indications, Dosage, Side Effects and Precautions

This medication is a nonsteroidal anti-inflammatory agent(NSAIA), used to treat pain and inflammation associated with muscle, bone and joint disorders such as rheumatoid arthritis and osteoarthritis. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

Active peptic ulceration; severe liver impairment; patients in whom other NSAIDs or aspirin are likely to induce asthma, severe allergic reactions, pregnancy (3rd trimester), nursing mothers, perioperative pain during heart bypass (CABG).

Adult: Oral- 1 g as a single dose in the evening, followed by 0.5-1 g in the morning if needed.

It comes as a tablet to take by mouth, with or without food.

• Caution should be exercised in patients with history of pre-existing cardiovascular risk factors or disease; fluid retention, high blood pressure, digestive tract ulcers, elderly or debilitated patients, other forms of asthma, liver disease.

• It could cause heart attack and stroke especially in patients already at a risk.

• Closely monitor patients with any abnormal liver function test, and kidney disease. Withhold for at least 4-6 half-lives prior to surgical or dental procedures.

•  Most Common: Diarrhea, dyspepsia, and abdominal pain.
•  Gastrointestinal: Gastritis, gastrointestinal ulcers and bleeding, Constipation, flatulence, nausea, , dry mouth, difficulty in swallowing , mouth ulcer, vomiting, altered appetite, liver function abnormalities including liver failure.
•  Central Nervous System: Dizziness, headache, fatigue, increased sweating, sleeplessness, nervousness, drowsiness, weakness, agitation, anxiety, confusion, depression, tingling, tremor, fainting.
•  Skin: Mild to severe allergic reactions, increased sensitivity to light.
•  Heart: Inflammation of blood vessels. It could increase the incidence of heart attack and stroke.
•  Respiratory: Difficulty in breathing, lung inflammation.
•  Genitourinary: Decrease in kidney function, , kidney failure, vaginal bleeding.
•  Eye and ENT: Ringing in the ear, abnormal vision.
•  Blood: Decrease in platelets.
•  Metabolic: Weight gain.
•  Miscellaneous: Swelling of the leg.
•  Hypersensitivity: Serious allergic reactions which lead to death.

Do not take aspirin while using this medication.

Oral: Store it at room temperature (20-25°C). Store it in an airtight container, and keep away from children.