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Molgramostim - Indications, Dosage, Side Effects and Precautions

Last Updated on Nov 08, 2017
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General Information on Molgramostim

Generic Name : Molgramostim
Latest prescription information about Molgramostim. Learn its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Immunomodulators

Trade Names/Brand Names of Molgramostim

Leucomax, Macrogen

Overview of Molgramostim

Molgramostim is an immunomodulator used to stimulate the production of neutropenia due to chemotherapy.

Why is Molgramostim Prescribed? (Indications)

Molgramostim is an immune stimulator which is prescribed to correct neutropenia -the condition that causes low levels of neutrophils - following a high dose chemotherapy regimen or bone marrow transplantation.

It is a granulocyte macrophage colony-stimulating factor (GM-CSF), a human protein which is also recommended for the treatment of ganciclovir induced neutropenia.

It is also used in acute respiratory distress syndrome, a life threatening condition because of the difficulty in breathing.

This drug is not approved in most places, including the US. The UK has granted orphan drug status for the treatment of acute respiratory distress syndrome. 


When should Molgramostim not be taken? (Contraindications)

Molgramostin is contraindicated, should be avoided or used with caution in the following conditions:

Allergy to the drug
Patient undergoing chemotherapy or radiotherapy for bone marrow malignancies
Heart failure and cardiac arrhythmia
Pre-existing asthma or other lung disease
Fluid retention

What is the dosage of Molgramostim?

The recommended adult doses for its indications are as follows:

Treatment of chemotherapy induced neutropenia:
The initial dosage is 5-10 mcg/kg for 7-10 days as a subcutaneous injection. The maximum dosage is 10mcg/kg/day.

Treatment of complications in bone marrow transplantation:
Initially 10mcg/kg/day as an intravenous infusion for 4 to 6 hours on the first day of bone marrow transplantation.
The maximum dosage is 10mcg/kg/day.
The treatment to be continued for about 1 month.

Ganciclovir induced neutropenia:
A dosage of 5mcg/kg daily as a subcutaneous injection.
The maximum dosage is 10mcg/kg daily.
After obtaining the polymorphonuclear cell (PMN) counts after the fifth dose, the dosage can be adjusted.

How should Molgramostim be taken?

Molgramostim is available as sub-cutaneous injection as well as an intravenous infusion. It is used as an inhalation for acute respiratory distress syndrome.
The vial containing the medication should be allowed to reach the room temperature by keeping out from the cold storage 30 minutes before injecting.

What are the warnings and precautions for Molgramostim?

The treatment to be stopped if patients develop pulmonary infiltrates.
Dosage adjustment is required in liver and kidney impairment.

What are the side effects of Molgramostim?

  Gastrointestinal Tract: Diarrhea, nausea, loss of appetite, stomach upset
  Cardio vascular system: Pleural and pericardiac effusion (fluid accumulation around the lung and the heart), cardiac arrhythmia (abnormal heart rhythm), transient hypotension (low blood pressure)
  Respiratory: Breathing difficulty
  Musculoskeletal: Muscle or bone pain, muscle aching or weakness
  Skin: Rashes, swelling, redness or pain at the injection site
  Others: Chills, fever, headache, swelling of the feet, sudden weight gain, dizziness, severe allergic reaction

What are the other precautions for Molgramostim?

A complete blood cell count has to be monitored during molgramostim therapy.

What are the Drug Interactions of Molgramostim?

Bleomycin: Molgramstim may increase the risk of bleomycin induced pulmonary toxicity.
Anti-cancer drugs: Do not administer molgramostim within 24 hours of myelosuppressive (bone marrow suppressive) cytotoxic anti-cancer drugs as there may be a high risk of bone marrow suppression.

What are the storage conditions for Molgramostim?

Store at between 2 - 8C.
Not to be frozen.
To be protected from light.

Last Updated : 11/8/2017

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