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General Information on Midodrine

Generic Name : Midodrine

Pronunciation : MIH-doe-DREEN

Latest prescription information about Midodrine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y52.9 | Therapeutic Classification : Antihypotensives

Trade Names/Brand Names of Midodrine

International- Orvaten , ProAmatine.

Why is Midodrine Prescribed? (Indications)

This medication is an antihypotensive and vasopressor, prescribed for orthostatic hypotension (low blood pressure when standing) and narrowing of the blood vessel, which leads to an increase in blood pressure. It is also prescribed for chronic fatigue syndrome (condition characterized by low stamina, fatigue, muscle pain and depression).  

When should Midodrine not to be taken? (Contraindications)

Contraindicated in patients with severe organic heart disease (specific organ (heart) damaged by an event), acute renal (kidney) disease, urinary retention, neuro endocrine tumor of the medulla (cancer in adrenal gland) or excess production of thyroid hormone. It is not administered in patients with persistent and excessive supine hypertension (increased level of blood flow resistance).

What is the dosage of Midodrine?

Adult: PO- Orthostatic hypotension- 10 mg 3 times per day, last dose to be taken at least 4 hours before bedtime.

How should Midodrine be taken?

It comes as a tablet to take by mouth as directed by your physician.

What are the warnings and precautions for Midodrine?

Caution should be exercised in patients with history of heart disease (blood vessel problem or high blood pressure), liver disease, decrease in the level of thyroid hormone, diabetes, stroke, kidney impairment, pregnancy and breastfeeding.

Caution needed for patients with visual complications like glaucoma (damage of the optic nerve).

What are the side effects of Midodrine?

  Most Common: Chills, goose bumps, abdominal pain, dry mouth, facial flushing, decreased pulse rate and allergic reactions.
  Genitourinary: Frequent urination, retention of urine, impaired urination and pain during urination.
  Skin: Tingling and numbness.
  Eye: Visual defects.
  Central Nervous System: Confusion, nervousness, anxiety, dizziness and fainting.
  Respiratory : Shortness of breath.

What are the other precautions for Midodrine?

Avoid excess dosage.

What are the storage conditions for Midodrine?

Oral: Store it at room temperature (25C), and in an airtight container.

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