This medication is an endogenous inhibitor used in diagnosis of adrenal insufficiency and in the treatment of Cushing's syndrome (excess amount of cortisol in the body). It blocks the production of hormones in body such as cortisol and corticosterone.
Contraindicated in patients with adrenal cortical insufficiency or hypersensitivity.
Single-Dose Short Test-
For Outpatients: The recommended dose is 30 mg/kg (maximum 3 g) at midnight with yogurt or milk.
Multiple-Dose Test- Day 1: Control period - Collect 24-hour urine for measurement of 17-OHCS or 17-KGS.
Day 2: ACTH test to determine the ability of adrenals to respond - Standard ACTH test such as infusion of 50 units ACTH over 8 hours and measurement of 24-hour urinary steroids. If results indicate adequate response, the test may proceed.
Day 3-4: Rest period.
Day 5: Administration: Recommended with milk or snack.
Adults: 750 mg orally, every 4 hours for 6 doses. A single dose is approximately equivalent to 15 mg/kg.
Children: 15 mg/kg orally every 4 hours for 6 doses. A minimal single dose of 250 mg is recommended.
Day 6: After administration - Determination of 24-hour urinary steroids for effect.
The results will be interpreted.
It comes as a capsule to take by mouth, as directed by your physician.
• Caution should be exercised in patients with history of thyroid deficiency, adrenal insufficiency, heart, liver or kidney disease, high blood pressure, during pregnancy and breastfeeding.
• It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.
• Heart: Low blood pressure.
• Gastrointestinal : Nausea, vomiting and abdominal discomfort or pain.
• Central Nervous System: Headache, dizziness and sedation.
• Skin: Allergic rash.
• Blood: Rarely, decreased white blood cell count or bone marrow depression can occur.
Avoid alcohol consumption and abrupt withdrawal.
Store it at room temperature and in an airtight container. Keep away from children.
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