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Melphalan - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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General Information on Melphalan

Generic Name : Melphalan
Pronunciation : mel' fa lan
Latest prescription information about Melphalan. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
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Trade Names/Brand Names of Melphalan

India : 

International : 

Alkeran
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Why is Melphalan Prescribed? (Indications)

This medication is a chemotherapy agent, prescribed for multiple myeloma, melanoma, and ovarian carcinoma.  It stops or slows the growth of cancer cells in the body.

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When should Melphalan not be taken? (Contraindications)

Contraindicated in patients with severe bone marrow suppression and hypersensitivity.

What is the dosage of Melphalan?

PO- Multiple Myeloma: The usual oral dose is 6 mg (3 tablets) daily. The entire daily dose may be given at one time.
Epithelial Ovarian Cancer: dose of 0.2 mg/kg daily for 5 days as a single course. Melanoma: 0.6-1 mg/kg.

How should Melphalan be taken?

It comes as a tablet to take by mouth, on an empty stomach. It also comes as a solution for injection to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Melphalan?

Caution should be exercised in patients with history of bone marrow depression, infection, low white blood cell count, kidney problems, shingles, chickenpox, under going radiation therapy, any allergy, who are taking other medications, children, during pregnancy and breastfeeding.

Avoid contact with people who have infections.

It may affect platelet counts; to prevent bleeding avoid injury or bruising.

Monitor complete blood counts regularly while taking this medication.

What are the side effects of Melphalan?

   Most common : Bone marrow suppression.
   Gastrointestinal : Nausea, vomiting, diarrhea and oral ulceration.
   Liver : Abnormal liver function, jaundice and liver inflammation.
   Miscellaneous : Lung scar, lung inflammation, skin hypersensitivity, rash, inflammation of blood vessels, hair loss and anemia.
   Allergic reactions : Hives, swelling, and rarely shock.

What are the other precautions for Melphalan?

Avoid excess dosage.

What are the storage conditions for Melphalan?

Store it in the refrigerator (2 to 8C), and keep away from children.




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