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Mefenamic Acid - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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General Information on Mefenamic Acid

Generic Name : Mefenamic Acid
Pronunciation : me fe nam' ik
Latest prescription information about Mefenamic Acid. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y45.3 | Therapeutic Classification : Analgesics

Why is Mefenamic Acid Prescribed? (Indications)

This medication is a non-steroidal anti-inflammatory drug (NSAID), prescribed for dysmenorrhea and other pain. It decreases inflammation and uterine contractions. 


When should Mefenamic Acid not be taken? (Contraindications)

Contraindicated in patients who have experienced asthma, hives, allergic reactions after taking aspirin or other NSAIDs, peri-operative pain, ulcer, kidney disease and hypersensitivity.

What is the dosage of Mefenamic Acid?

PO- The recommended dose is 500 mg as an initial dose followed by 250 mg every 6 hours as needed.

How should Mefenamic Acid be taken?

It comes as a tablet and capsule to take by mouth, with or without food.

What are the warnings and precautions for Mefenamic Acid?

• Caution should be exercised in patients with history of high blood pressure, blood disorders, bleeding or clotting problems, heart disease, dehydration, alcoholism, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.

• It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.

• Patient may develop with stomach ulcer or bleeding, so avoid long-term use of this medication.

• Avoid taking aspirin with this medication.

• Monitor kidney function, complete blood cell counts, and blood pressure regularly while taking this medication.

What are the side effects of Mefenamic Acid?

   Gastrointestinal : Abdominal pain, constipation, diarrhea, indigestion, flatulence, gross bleeding/perforation, gastric/peptic ulcers, heartburn, nausea, mouth ulcer, GI ulcers, vomiting, anemia, elevated liver enzymes, and blood vomiting.
   Body as a whole : Fever, infection and sepsis.
   Heart : Heart failure, high blood pressure, fast heart rate and fainting.
   Liver : Liver inflammation and jaundice.
   Blood : Eosinophilia, decrease in white blood cells, bruising, blood in stool and rectal bleeding.
   Metabolic : Weight changes.
   Central Nervous system : Anxiety, weakness, confusion, depression, dream abnormalities, drowsiness, dizziness, sleeplessness, uneasiness, headache, nervousness, tingling and tremors.
   Respiratory : Asthma and difficulty in breathing.
   Skin : Hair loss, sensitivity to light, itching and increased sweating.
   Eye and ENT : Blurred vision and ringing in the ear.
   Genitourinary : Bladder inflammation, painful urination, blood in urine and kidney failure.

What are the other precautions for Mefenamic Acid?

Avoid excess dosage.

What are the storage conditions for Mefenamic Acid?

Store it at room temperature (20- 25°C).

<>Schedule : HPrescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.


CarinSSmit, United Kingdom

Why would a doctor put a 9 year old autistic child on Ponstel???? It makes absolutely NO sense! She has a proven history of inflammatory bowel disease!

msuryanarayan, India

After withdrawn of nimesulide susp. in IPM some padiaticians prefering paracetamol+mefenamic acid susp.as antipyretics , whether it is safe, efficacious in children?

Raheel, Pakistan

Sir, I m the student of B-pharmacy, I have some question regarding Anti infilamentary drugs, Why we use the mefenamic Acid other then NSAIDS

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