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Mecasermin [rDNA origin] Injection - Indications, Dosage, Side Effects and Precautions

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Information about Mecasermin [rDNA origin] Injection

Generic Name : Mecasermin [rDNA origin] Injection
Latest prescription information about Mecasermin [rDNA origin] Injection. Learn its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Insulin-like Growth Factor
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Trade Names/Brand Names of Mecasermin [rDNA origin] Injection

International- Increlex.
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Why is Mecasermin [rDNA origin] Injection Prescribed? (Indications)

This medication is recombinant human insulin-like growth factor 1 (IGF-I), prescribed for growth failure in children with severe primary IGF-1 deficiency, and growth hormone (GH) gene deletion who have developed neutralizing antibodies to GH. 
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When should Mecasermin [rDNA origin] Injection not be taken? (Contraindications)

Contraindicated in the presence of active or suspected malignancy, closed epiphyses, and known hypersensitivity.

What is the dosage of Mecasermin [rDNA origin] Injection?

SC- The recommended starting dose is 0.04 to 0.08 mg/kg (40 to 80 micrograms/kg) twice daily.

How should Mecasermin [rDNA origin] Injection be taken?

It comes as a solution for injection, to be administered by a healthcare provider under the skin.

What are the warnings and precautions for Mecasermin [rDNA origin] Injection?

• It should not be administered intravenously.

Caution should be exercised in patients with history of high blood pressure, decreased blood sugar, stroke, femoral epiphysis, over growth of tissues, liver or kidney impairment, preexisting scoliosis, any allergy, during pregnancy and breastfeeding.

What are the side effects of Mecasermin [rDNA origin] Injection?

   Most Common : Decreased blood sugar, allergic reactions, stroke, tonsils growth.
   General : Lump under the skin, bruising.
   Infection : Ear infection.
   Respiratory : Snoring.
   Central Nervous System : Headache, dizziness and convulsions.
   Gastrointestinal : Vomiting.
   ENT : Hearing sensitivity, fluid in middle ear, ear pain, abnormal tumor in the middle ear.
   Heart : Heart murmur.
   Musculoskeletal : Joint pain, pain in extremity.
   Blood : Thymus hypertrophy.
  Skin:Hair loss.

What are the other precautions for Mecasermin [rDNA origin] Injection?

Avoid excess dosage.

What are the storage conditions for Mecasermin [rDNA origin] Injection?

Store the medication as directed by your physician.



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