About Careers Internship MedBlogs Contact us

Larotrectinib - Indications, Dosage, Side Effects and Precautions

Font : A-A+

General Information on Larotrectinib

Generic Name : Larotrectinib
Pronunciation : Lar-oh-trek-ti-nib
Latest prescription information about Larotrectinib. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, warnings and its storage instructions . Also listed are the Indian trade name(s) of the drug and its price list.

Trade Names/Brand Names of Larotrectinib


Overview of Larotrectinib

Larotrectinib is an anticancer drug(kinase inhibitor) that is used to treat solid tumors in adults and children having certain gene modifications. Solid tumors are an abnormal mass of tissue that does not contain liquid areas and cysts. 

Why is Larotrectinib Prescribed? (Indications)

Larotrectinib is an anticancer agent that is indicated for treatment of solid tumors in adults and children. It is specifically used in patients having gene modifications like NTRK gene fusion. 

When should Larotrectinib not be taken? (Contraindications)

1.Allergy to the drug
2.Pregnant women
3.Breastfeeding women

What is the dosage of Larotrectinib?

For adults and children- Capsule- 25mg, 100mg.  Oral solution- 20mg/mL. The dose recommended of larotrectinib is 100mg orally twice daily with or without food for atleast 6 months.

How should Larotrectinib be taken?

Capsules and solutions are available which can be taken by orally. For oral solution, always use the syringe given to measure the dose.

Missed a Dose?

Do not take a missed dose if the next dose is to be taken within 6 hours. If the person vomits after administration of a dose, next dose should be taken according to the schedule.

What are the side effects of Larotrectinib?

1.General: Fatigue, swelling of lower legs or hands, fever
2.Gastrointestinal: Nausea, vomiting, constipation, diarrhea, abdominal pain
3.Nervous system: Dizziness, headache
4.Respiratory: Cough, nasal congestion, shortness of breath
5. Vascular: Hypertension
6.Muscles and Joints: Back pain, joint pain, muscle pain, pain in the extremities, muscle weakness.
7. Miscellaneous: Weight gain, Anemia, Decreased appetite, Infertility in females.

What are the other precautions for Larotrectinib?

1.Monitor liver function tests every two weeks during the first month and after that monthly. Reduce the starting dose of larotrectinib in patients with moderate liver function impairment.
2.Neurological adverse effects like gait disturbances, dizziness, tremors, delirium, memory impairment can be seen.
3.Patients are advised not to operate heavy machines if they experience these adverse effects.
4. In females who are able to get pregnant, proper contraceptives should be used during the treatment and one week after the last dose is given.
5. In males with female partners who are able to pregnant, proper contraceptives should be used during the treatment and one week after the last dose is given.
6.Patients should inform their doctors about all the medications they take including herbal medications, OTC products, and vitamin supplements.
7.Do not eat grapefruit or drink grapefruit juice.
Do not take St John Wort.

What are the Drug Interactions of Larotrectinib?

Avoid administration of larotrectinib with the following drugs:
4.Phenobarbitone etc. 

What are the storage conditions for Larotrectinib?

Capsules: store at room temperature 20-25C Oral Solution: Store in refrigerator having temperature 2-8C. Do not freeze. Throw away unused oral solution remaining 90 days after opening the bottle.
Last Updated : 1/29/2021

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.

Drugs A - Z
Drugs Search

    What's New on Medindia
    Monkeypox Outbreak: What it is, How Does it Spread & the Prevention
    Seasonal Allergy Medications
    How to Choose the Best Eczema-Friendly Moisturizer for Children?
    View all

    Medindia Newsletters Subscribe to our Free Newsletters!
    Terms & Conditions and Privacy Policy.

    Most Popular on Medindia

    Daily Calorie Requirements Find a Doctor Drug Side Effects Calculator Sinopril (2mg) (Lacidipine) Noscaphene (Noscapine) Loram (2 mg) (Lorazepam) Indian Medical Journals Diaphragmatic Hernia Color Blindness Calculator Turmeric Powder - Health Benefits, Uses & Side Effects

    Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

    © All Rights Reserved 1997 - 2022

    This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use