This medication is a monoclonal antibody, prescribed for non-Hodgkin's lymphoma with other medications. It works by killing certain blood and cancer cells from body immune system.
Contraindicated in patients with bone marrow depression and hypersensitivity.
Step 1: Infuse rituximab 250 mg/m 2 at a rate of 50 mg/h, escalate the dose up to 400mg/hr. After this administer indium-111 (In-111) ibritumomab tiuxetan 5 mCi (1.6 mg total antibody dose) administered as a 10-min IV push.
Step 2: Continue this procedure for 7 to 9 days.
It comes as a solution for injection to be administered by a healthcare provider into the vein.
• Caution should be exercised in patients with history of blood disorders, decrease in complete blood cell counts due to bone marrow depression, any allergy, who are taking other medications, during pregnancy and breastfeeding.
• It may cause dizziness, do not drive a car or operate machinery while taking this medication.
• It may reduce platelet counts; avoid injury or bruising.
• Avoid contact with people who have infections.
• Patient may develop with increased the risk of certain blood cancers; consult with your doctor before taking this medication.
• Avoid live vaccination during the treatment period.
• Monitor complete blood counts regularly while taking this medication.
• Most Common :
Reduction in the number of blood cells, fatigue, abdominal pain, nausea, cold, weakness, diarrhea, cough and fever.
• Body as a Whole : Influenza-like illness.
• Musculoskeletal : Muscle pain and loss of appetite.
• Respiratory : Cough, throat pain, upper respiratory tract infection and nosebleed.
• Central Nervous System : Dizziness.
• Heart : High blood pressure.
• Skin : Night sweats, blister, itching and rash.
• Genitourinary : Urinary tract infection.
Avoid excess dosage.
Store it in refrigerator (2-8°C). Do not freeze.
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