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Gliclazide - Indications, Dosage, Side Effects and Precautions

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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Information about Gliclazide

Generic Name : Gliclazide
Pronunciation : GLIK-la-zide
Latest prescription information about Gliclazide. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y42.3 | Therapeutic Classification : Antidiabetics
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Trade Names/Brand Names of Gliclazide

India : 

More...

International : 

Diamicron
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Why is Gliclazide Prescribed? (Indications)

This medication is an oral hypoglycemic (anti-diabetic drug), prescribed for type 2 diabetes. It stimulates the pancreas, which helps in more insulin secretion.
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When should Gliclazide not be taken? (Contraindications)

Contraindicated in patients with diabetic-ketoacidosis, severe liver and kidney impairment, and hypersensitivity.

What is the dosage of Gliclazide?

PO- Initially start with 160mgs daily in two divided doses. May go up to 320 mgs daily in two divided doses.

How should Gliclazide be taken?

It comes as a tablet to take by mouth, with food.

What are the warnings and precautions for Gliclazide?

• Caution should be exercised in patients with history of liver, kidney problems, any allergy, during pregnancy and breastfeeding.

• Monitor bloodsugar level regularly while taking this medication.

What are the side effects of Gliclazide?

GI disturbances, skin reaction, decrease in blood cell counts, jaundice, vomiting, diarrhea and stomach inflammation.

What are the other precautions for Gliclazide?

Avoid excess dosage.

What are the storage conditions for Gliclazide?

Store it at room temperature.

Schedule : H
Prescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.
Last Updated : Sep.2017



Gliclazide : Frequently Asked Questions

Q: What happens if Gliclazide is taken on an empty stomach?

A: Gliclazide should be taken 30 minutes before breakfast. Gliclazide promotes more appropriate insulin release and better glucose disposition when taken 30 minutes before breakfast than when taken with breakfast(1 Trusted Source
Influence of food intake on the absorption and effect of glipizide in diabetics and in healthy subjects

Go to source
).

Q: Does Gliclazide affect liver?

A:  Sulfonylureas have been linked to an increased risk of drug-induced idiosyncratic liver disease. A diabetic patient developed acute icteric liver necro-inflammation after starting gliclazide therapy(2 Trusted Source
Gliclazide-induced acute hepatitis

Go to source
).

Q: Does Gliclazide have antiplatelet activity?

A: Gliclazide not only has a hypoglycemic action but also possesses antiplatelet activity by inhibiting platelet aggregation via the serotonin pathway(3 Trusted Source
Effects of gliclazide on platelet aggregation and the plasminogen activator inhibitor type 1 level in patients with type 2 diabetes mellitus

Go to source
).

Q: Is Gliclazide contraindicated in pregnancy?

A: The use of oral diabetes medications during pregnancy is not advised due to known adverse effects on the fetus, such as congenital abnormalities, fetal hyperinsulinemia, and neonatal hypoglycemia(4 Trusted Source
Normal pregnancy and healthy child after continued exposure to gliclazide and ramipril during pregnancy

Go to source
).

Q: Is Glipizide same as Gliclazide?

A: Glipizide and gliclazide are not the same medication. Gliclazide and glipizide belong to the same sulfonylurea class(5 Trusted Source
Sulfonylureas

Go to source
).

  • 1. Influence of food intake on the absorption and effect of glipizide in diabetics and in healthy subjects - (https://pubmed.ncbi.nlm.nih.gov/7002565/)
  • 2. Gliclazide-induced acute hepatitis - (https://pubmed.ncbi.nlm.nih.gov/10656221/#:)
  • 3. Effects of gliclazide on platelet aggregation and the plasminogen activator inhibitor type 1 level in patients with type 2 diabetes mellitus - (https://pubmed.ncbi.nlm.nih.gov/20070990/#:)
  • 4. Normal pregnancy and healthy child after continued exposure to gliclazide and ramipril during pregnancy - (https://pubmed.ncbi.nlm.nih.gov/19109210/)
  • 5. Sulfonylureas - (https://www.ncbi.nlm.nih.gov/books/NBK513225/)
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Comments

sbsidh, India

I am type 2 diabetic, residing in Mumbai in state of Maharashtra in India.I basically travell a lot due to which my blood glucose level was not in control. I was prescribed with this glicazide [diamicron] 30mg and zita met 50/500 tablet . For 4 months I had this tablets. After 4 months there was no effect of this tablets on Glucose level.But there was lot negative side effect like abdomen pain, headache, nausea and it also made me depressed most of the time. Soon I had started with SB SIDH herbal medicine , which removed all the toxins from my body and my glucose level was under control. Now it has been 2 years I have stopped all diabetes tablets and leading a normal life. Blessings Mr .P.M.Shetty

robin1, India

I am taking glizid 80 once in a day for the last one month.It has controlled my sugar level but has affected sexuality severely

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