This medication is an anticoagulant or a blood thinner, prescribed for treatment of pulmonary embolism and prevention and treatment of deep vein thrombosis. It prevents clotting of blood. It is used along with warfarin for treatment of deep vein thrombosis and pulmonary embolism.
Contraindicated in patients with severe kidney disease, major bleeding episode, bacterial endocarditis, and low platelet levels associated with a positive in vitro test for anti-platelet antibody in the presence of fondaparinux sodium. Patients with weight less than 50 kg should not use fondaparinux for prevention of venous thromboembolism.
Adults—The dose is usually 2.5 to 10 mg injected under the skin once a day for prevention of deep vein thrombosis. Higher doses are needed for treatment of deep vein thrombosis and pulmonary embolism depending on the patient’s weight.
It comes as a solution to be injected (subcutaneously), by a healthcare provider.
• It may reduce platelet counts, avoid unusual bruising or bleeding.
• Monitor complete blood count, liver and kidney function regularly.
• Caution needed for elderly patients, children, and pregnant women.
• Patients on fondaparinux undergoing spinal procedures are at a higher risk for blood clots in the spine. Caution is needed in these patients.
• Most Common:
Mild bleeding, reduced platelet levels, irritation, rash or itching at the injection site.
• Blood: Bleeding, anemia, blood clot formation, post-operative bleeding and bruising.
• Central Nervous system: Sleeplessness, dizziness and confusion.
• Miscellaneous: Low blood pressure, low potassium in blood, increased liver enzymes and increased wound drainage.
Drugs such as aspirin could increase the risk of bleeding. Caution needed while taking such drugs with fondaparinux.
Store at 25°C. Store it at room temperature, and in an airtight container. Keep away from children and pets.
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