This medication is an antidote, prescribed for ethylene glycol or methanol poisoning either alone or with hemodialysis.
A loading dose of 15 mg/kg should be administered, followed by doses of 10 mg/kg every 12 hours for 4 doses, then 15 mg/kg every 12 hours thereafter until ethylene glycol or methanol concentrations are undetectable or have been reduced below 20 mg/dL, and the patient is asymptomatic with normal pH.
Dosage with Renal Dialysis: Injection is dialyzable and the frequency of dosing should be increased to every 4 hours during hemodialysis.
It comes as a solution for injection to be administered by a healthcare provider.
• It should not be given undiluted or by bolus injection (high quantity).
• Patient may develop with increased risk of severe allergic reactions; monitor signs and symptoms.
• Monitor blood sugar, kidney, liver functions and urine analysis regularly while taking this medication.
• Most Common:
Headache, nausea, dizziness, increased drowsiness and bad /metallic taste.
• Body as a Whole: Abdominal pain, fever, multi organ system failure, pain during injection, inflammation at injection site, backache and hangover.
• Heart: Slow/fast heart rate, inflammation of veins, shock and low blood pressure.
• Gastrointestinal: Vomiting, diarrhea, indigestion, heartburn, decreased appetite and liver damage.
• Blood: Eosinophillia, anemia, inflammation of lymph nodes, disseminated intravascular blood clot and anemia.
• Central Nervous System: Lightheadedness, seizure, agitation, feeling drunk, facial flush, fainting, night blindness, anxiety, "feeling strange" and decreased environmental awareness.
• Respiratory: Hiccups and inflammation of pharynx.
• Skin: Application site reaction and rash.
• Eye and ENT: Abnormal smell, speech/visual disturbances, transient blurred vision and roar in ear.
• Genitourinary: Absence of urine.
Safety and effectiveness needed for children, elderly, pregnant and breastfeeding women.
Store it at controlled room temperature (20 to 25Â°C), and in an airtight container.
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