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General Information on Fomepizole

Generic Name : Fomepizole

Pronunciation : foe MEP i zole

Latest prescription information about Fomepizole. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y57.2 | Therapeutic Classification : Antidotes

Trade Names/Brand Names of Fomepizole

International- Antizol.

Why is Fomepizole Prescribed? (Indications)

This medication is an antidote, prescribed for ethylene glycol or methanol poisoning either alone or with hemodialysis.  

When should Fomepizole not to be taken? (Contraindications)

Hypersensitivity.

What is the dosage of Fomepizole?

A loading dose of 15 mg/kg should be administered, followed by doses of 10 mg/kg every 12 hours for 4 doses, then 15 mg/kg every 12 hours thereafter until ethylene glycol or methanol concentrations are undetectable or have been reduced below 20 mg/dL, and the patient is asymptomatic with normal pH.
Dosage with Renal Dialysis: Injection is dialyzable and the frequency of dosing should be increased to every 4 hours during hemodialysis.

How should Fomepizole be taken?

It comes as a solution for injection to be administered by a healthcare provider.

What are the warnings and precautions for Fomepizole?

It should not be given undiluted or by bolus injection (high quantity).

Patient may develop with increased risk of severe allergic reactions; monitor signs and symptoms.

Monitor blood sugar, kidney, liver functions and urine analysis regularly while taking this medication.

What are the side effects of Fomepizole?

  Most Common: Headache, nausea, dizziness, increased drowsiness and bad /metallic taste.
  Body as a Whole: Abdominal pain, fever, multi organ system failure, pain during injection, inflammation at injection site, backache and hangover.
  Heart: Slow/fast heart rate, inflammation of veins, shock and low blood pressure.
  Gastrointestinal: Vomiting, diarrhea, indigestion, heartburn, decreased appetite and liver damage.
  Blood: Eosinophillia, anemia, inflammation of lymph nodes, disseminated intravascular blood clot and anemia.
  Central Nervous System: Lightheadedness, seizure, agitation, feeling drunk, facial flush, fainting, night blindness, anxiety, "feeling strange" and decreased environmental awareness.
  Respiratory: Hiccups and inflammation of pharynx.
  Skin: Application site reaction and rash.
  Eye and ENT: Abnormal smell, speech/visual disturbances, transient blurred vision and roar in ear.
  Genitourinary: Absence of urine.

What are the other precautions for Fomepizole?

Safety and effectiveness needed for children, elderly, pregnant and breastfeeding women.

What are the storage conditions for Fomepizole?

Store it at controlled room temperature (20 to 25°C), and in an airtight container.

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