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Esomeprazole - Indications, Dosage, Side Effects and Precautions

Last Updated on May 11, 2020
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Information about Esomeprazole

Generic Name : Esomeprazole
Pronunciation : ES-oh-MEP-ra-zole
Latest prescription information about Esomeprazole. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y53.0 | Therapeutic Classification : Antiulcers

Trade Names/Brand Names of Esomeprazole

India : 


International : 

Nexium IV

Why is Esomeprazole Prescribed? (Indications)

This medication is a proton pump inhibitor (PPI), prescribed for gastroesophageal reflux disease (GERD). With amoxicillin and clarithromycin it is used for treatment of Helicobacter pylori infection and duodenal ulcer. It is also used to aid in reduction in occurrence of gastric ulcers associated with continuous NSAID therapy, and in Zollinger-Ellison syndrome. It blocks the production of stomach acid. 

When should Esomeprazole not be taken? (Contraindications)

It should not be co-administered with Methotrexate, clopidogrel and atazanavir.

What is the dosage of Esomeprazole?

GERD: 20 or 40 mg is given once daily for 4-8 weeks. In children ages 1-11, the dose is 10 or 20 mg daily.
H. pylori: 40 mg is administered once daily in combination with amoxicillin and clarithromycin for 10 days.
NSAID-induced ulcers: 20 to 40 mg daily for 6 months.
Zollinger-Ellison syndrome is treated with 40 mg twice daily.

How should Esomeprazole be taken?

It comes as a tablet or capsule to take by mouth, once a day, one hour before meal.

What are the warnings and precautions for Esomeprazole?

• Caution needed for children, pregnancy and breastfeeding women.

It may cause malignancy and liver impairment.

While taking this medication, there is an increased risk of developing certain infections such as community-acquired pneumonia.

What are the side effects of Esomeprazole?

  Central Nervous System: Headache, dizziness, drowsiness, aggression, agitation, depression, hallucination.
  Skin: Itching, hair loss, severe allergic reactions, photosensitivity, blistering.
  Eye and ENT: Blurred vision.
  Gastrointestinal: Flatulence, abdominal pain, stomach upset, nausea, diarrhea, dry mouth, constipation, GI fungal infection, inflammation of pancreas and intestine, mouth ulcer, taste disturbance.
  Genitourinary: Breast enlargement in men, kidney disorder.
  Liver: Occurrence of confusion, altered level of consciousness and coma as a result of liver failure(Hepatic encephalopathy) , liver failure, inflammation of liver with or without jaundice.
  Blood: Decrease in white blood cells.
  Local: Injection-site reactions including mild local redness and itching with IV administration.
  Musculoskeletal: Muscular weakness, muscle pain.
  Respiratory: Asthma, respiratory tract infection.
  Miscellaneous: Severe allergic reaction/shock.

What are the other precautions for Esomeprazole?

Take properly as per your doctor's advice.

What are the storage conditions for Esomeprazole?

Injection: Powder for injection: Store at (20 - 25C). Protect from light. Reconstituted solution for injection should be stored at room temperature up to 30C and administered within 12 hr after preparation.

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NRI786, India

i have tried Nexium 40 and it works fine for GERD over three months. Now the new batch comes in 10 tabs against the previous 7 weekly dose. The new batch by Astra Zeneca is ineffective and I may switch to Glenmarks Esoz D . Is there a problem in long term use over a year or so....I have GERD and it invreases with spicy foods which I cant avoid,

nitaichandraray, India

very helpful guide for those patients who
take esomeprazole capsules regularly.
some side effects noted by me are
1) irritable bowel syndrome ,
2) allergic itches ,
3) hairfall.

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