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Eplerenone - Indications, Dosage, Side Effects and Precautions

Last Updated on August 11, 2022
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Information about Eplerenone

Generic Name : Eplerenone
Up-to-date prescription details regarding Eplerenone are provided here.
Pronunciation : eh-PLER-en-one
Learn the correct pronunciation of the Eplerenone, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.
Therapeutic Classification : Aldosterone Antagonists
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Trade Names/Brand Names of Eplerenone

India : 

International : 

Inspra
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Why is Eplerenone Prescribed? (Indications)

This medication is a mineral corticoid receptor antagonist, prescribed for high blood pressure and heart attack. It blocks the action of aldosterone, which aids in the regulation of blood pressure. 
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When should Eplerenone not be taken? (Contraindications)

Contraindicated in people with severe kidney or liver problem, co-administration with ketoconazole, itraconazole, serum potassium greater than 5.5 mEq/L, type 2 diabetes with microalbuminuria, serum creatinine greater than 2 mg/dL in men or greater than 1.8 mg/dl in women, Creatinine Clearance Rate (Ccr) 30 mL/min or less.

What is the dosage of Eplerenone?

Adults: PO- Start with 25 mg every day and titrate to target dose of 50 mg every day within 4 weeks as tolerated by the patient.

How should Eplerenone be taken?

It comes as a tablet to take by mouth, with or without food.

What are the warnings and precautions for Eplerenone?

• Caution should be exercised in patients with history of diabetes, gout, liver or kidney disease, increased potassium level in blood, any allergy, who are taking other medications, during pregnancy and breastfeeding.

It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.

What are the side effects of Eplerenone?

  Metabolic: Increase in blood cholesterol and sugar level.
  Gastrointestinal: Diarrhea and abdominal pain.
  Genitourinary: Presence of albumin in urine.
  Respiratory: Cough.
  Central Nervous System: Dizziness.
  Body as a Whole: Fatigue and influenza-like symptoms.

What are the other precautions for Eplerenone?

Avoid alcohol consumption.

What are the storage conditions for Eplerenone?

Store it at room temperature (25C).
Last Updated : August 11, 2022
Learn more about Eplerenone's interaction with Food, Herbs and Alcohol



Medindia adheres to strict ethical publishing standards to provide accurate, relevant, and current health content. We source our material from reputable places such as peer-reviewed journals, academic institutions, research bodies, medical associations, and occasionally, non-profit organizations. We welcome and value audience feedback as a part of our commitment to health literacy and informed decision-making.
  • 1. Eplerenone - (https://medlineplus.gov/druginfo/meds/a603004.html )
  • 2. Eplerenone : Interaction with Food, Herbs and Alcohol - (https://www.medindia.net/drugs/drug-food-interactions/eplerenone.htm)
  • 3. Long-term safety and efficacy of the selective aldosterone blocker eplerenone in patients with essential hypertension - (https://pubmed.ncbi.nlm.nih.gov/14604739/ )
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