This medication prevents blood clots in patients who are on bed rest or who are having orthopedic surgery of the hip replacement, knee replacement, or large intestinal surgery. It is a low molecular weight heparin.
It is indicated alone or in combination with warfarin to prevent and treat blood clots in the leg. It is a low molecular weight heparin. Enoxaparin is indicated for preventing and treating blood clots. Patients who are immobile for long duration are at increased risk of blood clot formation especially after prolonged bed rest due to surgeries.
Patients who are allergic to Enoxaparin, Heparin, Benzyl alcohol
Patients with excess bleeding
Patients with low platelet count
Enoxaparin is available as injection in 100 mg/mL concentration.
It is also available as Prefilled syringes, graduated prefilled syringe and multiple dose vials.
It is given as subcutaneous (into the fatty layer of skin) or intravenous (into the vein) injection.
Patients should take it as soon as they remember. Patients should not double their next dose or take more than the prescribed dose.
For preventing DVT in abdominal surgery, it is given as 40 mg subcutaneous once daily up to 12 days. It is recommended to be given as 30 mg SC every 12 hours up to 14 days DVT prophylaxis in hip and knee replacement surgery.
For acute heart attack, it is given as 30 mg single IV bolus plus a 1 mg/kg SC dose followed by 1 mg/kg SC every 12 hours at least 8 days along with aspirin.
Enoxaparin should not be mixed with other injections or infusions. It can be mixed with normal saline solution (0.9%) or 5% dextrose in water.
Heart: Abnormal heart rhythm, heart failure.
Skin: Cutaneous vasculitis(inflammation of blood vessels in the skin), easy bruising, discoloration of skin, skin necrosis occurring at the injection site or distant from the injection, blisters, rash.
Gastrointestinal: Nausea, diarrhea.
Blood: Anemia, major bleeding, reduced platelets, in some people increase in platelets.
Hypersensitivity: Systemic allergic reactions including anaphylactic/anaphylactoid reactions, itching, and hives.
Local: Pain, tenderness, irritation and redness, bleeding.
Genitourinary: Blood in urine.
Respiratory: Difficulty in sleeping, lung swelling and inflammation.
Liver: Increase in level of liver enzymes.
Miscellaneous: Mental confusion, fever, bleeding within the spinal cord, raised potassium level in the blood, swelling in the extremities.
Enoxaparin increases the risk of bleeding. So, pressure at the puncture site should be maintained for sometime
Use with caution in patients with increased bleeding risk such as - stomach ulcer, high blood pressure, diabetic retinal disease
Use with caution in patients with kidney problems
Monitor platelet count of patients before starting the injection and regularly thereafter
Do not exchange use of enoxaparin with heparin
Pregnant women with mechanical heart valves and their fetuses, may be at increased risk and may need more frequent monitoring and dosage adjustment.
There can be increased risk of bleeding if the following drugs are taken with Enoxaparin:
Injection: Store at 25°C. Store it in airtight container and keep away from children. Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F)
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