Encorafenib - Indications, Dosage, Side Effects and Precautions

Last Updated on August 11, 2022
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Information about Encorafenib

Generic Name : Encorafenib
Up-to-date prescription details regarding Encorafenib are provided here.
Pronunciation : en-koe-RAF-e-nib
Learn the correct pronunciation of the Encorafenib, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.
Therapeutic Classification : Chemotherapy

Trade Names/Brand Names of Encorafenib


Overview of Encorafenib

Encorafenib capsules for oral use are prescribed for treating adult patients with a specific type of advanced melanoma, a skin cancer with BRAF mutation.

Why is Encorafenib Prescribed? (Indications)

Encorafenib capsules for oral use are prescribed along with binimetinib for treating advanced melanoma which either cannot be removed by surgery or has moved to other parts of the body, in adult patients with BRAF V600E or V600K mutation confirmed by an FDA-approved test.

Tumor specimens should be tested for the presence of BRAF V600E or V600K mutation before starting the treatment with encorafenib. 

When should Encorafenib not be taken? (Contraindications)

Encorafenib should not be used in patients with-

Allergy to encorafenib
Wild-type BRAF skin cancer
Pregnancy and breastfeeding
Men undergoing fertility treatments

Encorafenib should not be used in children as safety and effectiveness studies of encorafenib have not been conducted in these age groups.

Caution is required in treating patients with-

History of bleeding
Heart rhythm abnormalities
Eye disorders

What is the dosage of Encorafenib?

The recommended adult dose of encorafenib is 450 mg taken one time daily in combination with binimetinib.

If any serious side effects occur, the dose of encorafenib can be reduced or modified to 300mg first, and then to 200 mg if needed.

Treatment with encorafenib can permanently be discontinued if the patient cannot tolerate 200 mg of encorafenib given once daily.

The dose of encorafenib can be reduced to 300 mg taken once daily if binimetinib is discontinued for some reasons and can be maintained at the same dose until binimetinib is initiated.

How should Encorafenib be taken?

Encorafenib comes in a capsule form that can be taken by mouth with or without food. Take encorafenib capsules with food if stomach irritation occurs.

If a dose of encorafenib is missed, take the missed dose as early as possible. Never take the missed dose of encorafenib if the next scheduled dose is within 12 hours.

Do not take an additional dose of encorafenib if vomiting occurs while taking encorafenib capsules but continue with the next dose as per the next scheduled time.

What are the warnings and precautions for Encorafenib?

Women of childbearing age should take an effective contraceptive measure during the treatment with encorafenib and continue taking contraceptives for at least two weeks after the last dose of encorafenib.

Breastfeeding mothers should not breastfeed their children during encorafenib treatment and for at least two weeks from the last dose.

A pregnancy test should be done on women of childbearing age before the therapy, and the treatment with encorafenib should be started only if the pregnancy test reads negative.

Men of reproductive potential should plan to store their sperms in a sperm bank before starting encorafenib treatment as it may affect their fertility status.

Patients should be monitored for any abnormalities in heart rhythm and dose with encorafenib can be reduced, or treatment may be discontinued if the rhythm has a prolongation greater than 500 milliseconds.

Look for any electrolyte abnormalities during the treatment with encorafenib and correct if any low levels of potassium or magnesium occur.

Skin examination should be performed before starting treatment with encorafenib that should be followed up every two months during the treatment and six months after stopping the encorafenib treatment.

Eye disorders including new or worsening of visual disturbances can occur with encorafenib treatment; therefore patients should be advised to meet an eye specialist and to check their eye function at regular intervals.

Bleeding events can occur during treatment with encorafenib and binimetinib combination. The most common is bleeding in the stomach and worsening of bleeding in hemorrhoids or piles which require treatment modification.

What are the side effects of Encorafenib?

  Gastrointestinal: Nausea, vomiting, pain in the stomach, constipation
  Musculoskeletal: Muscle pain, pain in the joints and extremities
  Nervous system: Headache, dizziness, numbness or pricking sensation in the hands or feet
  Skin: Rashes, itching, hair loss, dry skin
  Others: Weakness, fever, bleeding episodes, allergic reactions, painful nodules in the skin, high sugar level, alterations in sodium and magnesium level, blood disorders and other lab abnormalities.

What are the other precautions for Encorafenib?

Never change the dose or stop the treatment of encorafenib without the advice of the physician.

Do not take an additional dose of encorafenib to make up for the missed dose as it can cause serious side effects.

What are the Drug Interactions of Encorafenib?

Encorafenib may affect the effectiveness of hormonal contraceptives and should be avoided taken together.

Do not take drugs that cause heart rhythm abnormalities along with encorafenib as the condition may worsen with encorafenib treatment.

Avoid taking grapefruit juice with encorafenib as it may increase the amount of encorafenib in the body leading to life-threatening conditions.

Inform the doctor about taking any prescription, non-prescription or herbal supplements prior to taking encorafenib so as to avoid dangerous drug reactions with the latter.

What are the storage conditions for Encorafenib?

Store encorafenib capsules at room temperature between 20C and 25C.

Keep the encorafenib capsules in their original bottle and do not remove the desiccant provided inside the bottle as it protects the capsule from moisture.

Keep the encorafenib capsules away from children and pets.
Last Updated : August 11, 2022

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