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Last Updated : 12/26/2017

General Information on Dupilumab

Generic Name : Dupilumab

Pronunciation : doo-PIL-ue-mab

Latest prescription information about Dupilumab. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
Therapeutic Classification : Monoclonal antibodies

Trade Names/Brand Names of Dupilumab

Dupixent

Overview of Dupilumab

Dupilumab is a monoclonal antibody which was approved by US FDA in March 2017 to use as a subcutaneous injection for treating moderate-to-severe atopic dermatitis.

Why is Dupilumab Prescribed? (Indications)

Dupilumab is prescribed for the treatment of moderate-to-severe atopic dermatitis (a skin disorder in which the skin is dry and itchy with red and scaly rashes) in adult patients who do not respond to topical therapies or who cannot tolerate the medicines that are normally used to treat it.

Dupilumab is an interleukin 4-receptor alpha antagonist. It interferes with the signaling of the inflammatory mediators interleukin-4 and interleukin-13, thereby reducing the inflammation in the body.

Dupilumab is used along with topical corticosteroids or alone as a monotherapy. 

When should Dupilumab not to be taken? (Contraindications)

Dupilumab should not be used in patients-

Hypersensitivity or allergy to dupilumab
Children younger than 18 years of age
Existing eye disorders
Known parasite infections

What is the dosage of Dupilumab?

The recommended adult dose of dupilumab is 600mg (2 injections of 300mg each administered at two different sites of the body) as an initial dose which is followed by 300mg subcutaneously administered every other week.

Missed a Dose?

If a dose is missed, patients are advised to take the missed dose if it is within 1 week and then follow the prescribed schedule.
If the dose is missed for more than 1 week then the patients should skip the missed dose and take the next dose at the specified time schedule.

How should Dupilumab be taken?

Dupilumab comes as a pre-filled syringe which has to be injected under the skin as a subcutaneous injection.
Before injecting dupilumab, it is necessary to allow the medication to come to room temperature by keeping outside for around 45 minutes. It is not advised to heat it by keeping in the microwave oven or placing in hot liquids.
It is important to check the medication for the presence of any visible particles or cloudy appearance. If present, the injection must be discarded.
The injection sites are thighs or abdomen except at the navel and the area around 2 inches or 5 cm around the navel. Do not inject into the skin where the area is tender, red or bruised, or hard either with scars or stretch marks.

What are the warnings and precautions for Dupilumab?

Patients should be advised to report to the emergency center if any allergic reactions such as urticaria or serum sickness occur. In such cases, the treatment should be discontinued and the subjects should be treated appropriately.
Patients with asthma should not stop or adjust the treatment schedule of asthma while on dupilumab without consulting the treating physician.
Eye disorders such as conjunctivitis and keratitis frequently occur and patients should be intimated to report about the new onset or worsening of the eye disorders.
Parasitic infections should be treated prior starting dupilumab therapy.
Caution is advised in pregnancy and breastfeeding since adequate safety information is not available in these conditions.

What are the side effects of Dupilumab?

  Common: Pain or swelling at the injection site, puffy eyelids or redness of the eye, fever
  Gastrointestinal: Oral herpes
  Eye: Inflammation of the eyelid, cornea and/or conjunctiva, itching of the eye dryness of the eye, blurred vision
  Others: Other herpes simplex viral infections, allergic reactions, skin rashes, joint pain

What are the other precautions for Dupilumab?

The prefilled syringe should be used only once by injecting all the solution and the used syringe should be disposed off safely.
Do not shake the prefilled syringe and also care should be taken that not to be frozen.
The prefilled syringe can be kept at a cool room temperature for about 2 weeks but should not be replaced back into the refrigerator. If it kept more than 2 weeks at a cool room temperature, the injection should be discarded.

What are the Drug Interactions of Dupilumab?

Taking a live vaccine such as measles-mumps-rubella (MMR), chicken pox or influenza vaccine is not advised during the treatment with dupilumab.
Drugs of a narrow therapeutic index such as warfarin or cyclosporine should be cautiously used along with dupilumab by closely monitoring of the drug concentration or adverse effects so that the dose can be modified.
Prescription or over-the-counter drugs or herbal supplements should be taken along with dupilumab only after the approval of the physician to avoid serious drug interactions.

What are the storage conditions for Dupilumab?

Store dupilumab injection in a refrigerator at 2C to 8C in the original carton and must be protected from light.

Last Updated : 12/26/2017
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