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Dulaglutide - Indications, Dosage, Side Effects and Precautions

Last Updated on Dec 01, 2018
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Information about Dulaglutide

Generic Name : Dulaglutide
Pronunciation : doo la gloo tide
Latest prescription information about Dulaglutide. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the Indian trade name(s) of the drug and its price list.
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Trade Names/Brand Names of Dulaglutide

Trulicity
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Overview of Dulaglutide

Dulaglutide injection is used as an add-on therapy to diet and exercise to decrease blood glucose levels in adults with type 2 diabetes mellitus.

Why is Dulaglutide Prescribed? (Indications)

Dulaglutide is a glucagon-like peptide 1 (GLP-1) agonist used as an additional treatment to diet and exercise to decrease blood glucose in adults with type 2 diabetes mellitus. 
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When should Dulaglutide not be taken? (Contraindications)

Dulaglutide should not be used in patients:

If there is an allergy to dulaglutide or any other product components
With a personal or family history of thyroid carcinoma or in patients with type 2 Multiple Endocrine Neoplasia syndrome (a hormonal disorder)
As the main treatment option for patients inadequately controlled on diet and exercise.
With pancreatitis , alternate treatment should be considered.
For the treatment of type 1 diabetes mellitus or severe diabetes like diabetes ketoacidosis
With pre-existing severe gastrointestinal disease.

What is the dosage of Dulaglutide?

Dulaglutide is available as:
Injection: 0.75 mg/0.5 mL solution in a single-dose pen or prefilled syringe
Injection: 1.5 mg/0.5 mL solution in a single-dose pen or prefilled syringe for treating adults with type 2 diabetes

How should Dulaglutide be taken?

Dulaglutide injection should be given subcutaneously in the abdomen, thigh or upper arm once e every week at any time of the day.
The initial dose is 0.75 mg once a week. The dose can be increased to 1.5 mg for further lowering of blood glucose.

Missed a Dose?

If a dose of dulaglutide is missed, administer within 3 days of a missed dose

What are the warnings and precautions for Dulaglutide?

• Dulaglutide can cause an increased risk of thyroid cancer s depending on the dose. So, caution is needed in patients with high risk of thyroid cancer.

Patients should inform the symptoms of thyroid cancer like swelling in the neck, difficulty swallowing, difficulty breathing(dyspnea), changes in the voice. Regular monitoring of serum calcitonin and thyroid ultrasound is recommended.

Dulaglutide can cause hypoglycemia (very low blood glucose) when used with other drugs like sulfonylurea or insulin. The dose of the sulfonylurea or insulin should be reduced in such case to decrease the risk of hypoglycemia

In case of an allergic reaction, treat promptly until signs and symptoms resolve.

Monitor kidney functions in patients with kidney disorders reporting severe gastric related side effects.

What are the side effects of Dulaglutide?

Gastrointestinal: Nausea, diarrhea, vomiting, abdominal pain, decreased appetite, acidity
Cardiovascular: Arrhythmia (abnormal rhythm), increased heart rate (tachycardia)
Others: Fatigue, injection-site reactions like injection-site rash, redness
Lab abnormalities: Serum amylase, lipase levels should be monitored.

What are the other precautions for Dulaglutide?

Dulaglutide should be used during pregnancy only if the benefit justifies the risk to the baby.
The risk-benefit ratio should be considered while using dulaglutide in breastfeeding women.
Dulaglutide is not recommended in patients younger than 18 years.
Dulaglutide is not recommended in patients with gastroparesis (patients with slow stomach emptying).
Patients may experience gastrointestinal symptoms like nausea, vomiting, and hypoglycemia. Appropriate supportive care should be given in this case.

What are the Drug Interactions of Dulaglutide?

Dulaglutide may slow stomach emptying and may impact the absorption of concomitantly given oral medications.

What are the storage conditions for Dulaglutide?

Dulaglutide should be stored in the refrigerator at 36F to 46F (2C to 8C). It should not be used beyond the date of expiry.
In need arises, each single-dose pen or prefilled syringe can be kept at room temperature but this should not exceed 30C for a total of 14 days.
Dulaglutide should not be frozen. It must be protected from light. Storage in the original carton is recommended until the time of administration.
Discard dulaglutide single-dose pen or prefilled syringe after use in a puncture-resistant container.
Last Updated : 12/1/2018



Dulaglutide : Frequently Asked Questions

Q: Is Dulaglutide best taken at night?

A: Dulaglutide is usually taken once a week. It can be taken at any time of the day, with or without food . But it should be taken on the same day each week(1 Trusted Source
Information about Dulaglutide

Go to source
).

Q: Does Dulaglutide cause thyroid cancer?

A: Thyroid cancer is more common in people with type 2 diabetes than in non-diabetics. Dulaglutide is not recommended for patients who have a personal or family history of medullary thyroid carcinoma (2 Trusted Source
Dulaglutide (Trulicity): The Third Once-Weekly GLP-1 Agonist

Go to source
).

Q: Is Dulaglutide the same as insulin?

A: Dulaglutide is not the same as insulin . Dulaglutide belongs to a class of drugs called Glucagon-like Peptide-1 Agonists. Dulaglutide is similar to a naturally occurring hormone in the body (incretin)(3 Trusted Source
Dulaglutide Injection

Go to source
).

Q: Does Dulaglutide affect the heart?

A: Dulaglutide, commonly used to treat type 2 diabetes, is associated with an increased heart rate and reduced blood pressure . Dulaglutide should be used with caution in patients who already have an arrhythmia(4 Trusted Source
Exacerbation of atrial fibrillation related to dulaglutide use

Go to source
).

Q: Does Dulaglutide help with weight loss?

A: Dulaglutide is associated with weight loss in patients with type 2 diabetes, although it is not a weight-loss drug(5 Trusted Source
Effect of dulaglutide 3.0 and 4.5 mg on weight in patients with type 2 diabetes: Exploratory analyses of AWARD‐11

Go to source
).

  • 1. Information about Dulaglutide - (https://www.medindia.net/doctors/drug_information/dulaglutide.htm )
  • 2. Dulaglutide (Trulicity): The Third Once-Weekly GLP-1 Agonist - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894510/)
  • 3. Dulaglutide Injection - (https://medlineplus.gov/druginfo/meds/a614047.html#:)
  • 4. Exacerbation of atrial fibrillation related to dulaglutide use - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123549/)
  • 5. Effect of dulaglutide 3.0 and 4.5 mg on weight in patients with type 2 diabetes: Exploratory analyses of AWARD‐11 - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518850/#)
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