Email Print This Page Comment bookmark
Font : A-A+

General Information on Dolutegravir

Generic Name : Dolutegravir

Latest prescription information about Dolutegravir. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.

Trade Names/Brand Names of Dolutegravir

International- Tivicay.

Other Name(s) of Dolutegravir

DTG

Why is Dolutegravir Prescribed? (Indications)

This medication is an integrase inhibitor prescribed for the treatment of HIV-1 infection in adults and pediatric patients aged 12 years and older and weighing at least 40 kg. Dolutegravir works by blocking integrase, an HIV enzyme that prevents the replication and lowers the amount of HIV in the blood. 

When should Dolutegravir not to be taken? (Contraindications)

Coadministration of dolutegravir with dofetilide is contraindicated due to the potential for increased dofetilide plasma concentrations and the risk for serious and/or life-threatening events; hypersensitivity.

What is the dosage of Dolutegravir?

For treatment-nave adults as well as treatment-experienced adults who are INSTI (integrase strand transfer inhibitor) - nave: 50 mg tablet taken once daily.
For treatment-experienced adults who are INSTI-experienced with certain INSTI-associated resistance substitutions or clinically suspected INSTI resistance: 50 mg tablet taken twice daily.
For children aged 12 years and older and weighing at least 40 kg who are treatment-nave or treatment-experienced INSTI-nave: 50 mg tablet taken once daily.

How should Dolutegravir be taken?

It comes as a tablet to be taken by mouth with or without food.

What are the warnings and precautions for Dolutegravir?

Caution should be exercised in patients with history of hepatitis B and C, moderate or severe liver impairment, excess fat, pregnancy and children.

Monitor liver enzymes regularly.

Tivicay should not be used in patients who have experienced a previous hypersensitivity reaction to TIVICAY.

Appropriate laboratory testing prior to initiating therapy and monitoring for hepatotoxicity during therapy with TIVICAY are recommended.

What are the side effects of Dolutegravir?

Nausea, diarrhea, headache, dizziness, fatigue, weakness, increased cholesterol and triglycerides, hyperglycemia, increased creatinine kinase and upset stomach or indigestion, changes in body fat (lipodystrophy), changes in the immune system (immune reconstitution syndrome), trouble sleeping.

What are the other precautions for Dolutegravir?

Take the missed dose as soon as you remember it. But if it is within 4 hours of your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.

What are the storage conditions for Dolutegravir?

Store at 25C (77F); excursions permitted 15 to 30C (59 to 86F).

Advertisement

Recommended Reading

Show More Related Topics

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions
mubin123, India

is this drug available in india

Buy Medicines (Drug) at Concessional Price from India

Drugs A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Drugs Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store