This medication is an integrase inhibitor prescribed for the treatment of HIV-1 infection in adults and pediatric patients aged 12 years and older and weighing at least 40 kg. Dolutegravir works by blocking integrase, an HIV enzyme that prevents the replication and lowers the amount of HIV in the blood.
Coadministration of dolutegravir with dofetilide is contraindicated due to the potential for increased dofetilide plasma concentrations and the risk for serious and/or life-threatening events; hypersensitivity.
For treatment-naïve adults as well as treatment-experienced adults who are INSTI (integrase strand transfer inhibitor) - naïve: 50 mg tablet taken once daily.
For treatment-experienced adults who are INSTI-experienced with certain INSTI-associated resistance substitutions or clinically suspected INSTI resistance: 50 mg tablet taken twice daily.
For children aged 12 years and older and weighing at least 40 kg who are treatment-naïve or treatment-experienced INSTI-naïve: 50 mg tablet taken once daily.
It comes as a tablet to be taken by mouth with or without food.
• Caution should be exercised in patients with history of hepatitis B and C, moderate or severe liver impairment, excess fat, pregnancy and children.
• Monitor liver enzymes regularly.
• Tivicay should not be used in patients who have experienced a previous hypersensitivity reaction to TIVICAY.
• Appropriate laboratory testing prior to initiating therapy and monitoring for hepatotoxicity during therapy with TIVICAY are recommended.
Nausea, diarrhea, headache, dizziness, fatigue, weakness, increased cholesterol and triglycerides, hyperglycemia, increased creatinine kinase and upset stomach or indigestion, changes in body fat (lipodystrophy), changes in the immune system (immune reconstitution syndrome), trouble sleeping.
Take the missed dose as soon as you remember it. But if it is within 4 hours of your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
Store at 25°C (77°F); excursions permitted 15° to 30°C (59° to 86°F).
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