This medication is a chelating agent, indicated in the treatment of metal poisoning with metals such as arsenic, gold and mercury. It is an adjunct to Calcium Disodium Edetate in lead poisoning, and also an adjunct to penicillamine to copper poisoning and Wilson Disease.
Extensive liver failure; lactation, hypersensitivity, iron and cadmium poisoning.
Adult: IM- Heavy metal poisoning- Initial: 400-800 mg on the 1st day followed by 200-400 mg on the 2nd and 3rd days. Reduce to 100-200 mg subsequently. To be given in divided doses at 4-hourly intervals. Adjunct in lead poisoning Initial: 4 mg/kg followed by 3-4 mg/kg 4 hourly. Maintenance: 2-7 days.
It comes as a solution for injection to be administered by a healthcare provider into a large muscle.
• Caution should be exercised in patients with history of kidney damage, high blood pressure, G6PD (glucose-6-phosphate dehydrogenase) deficiency, elderly, pregnancy and lactation.
Antihistamines given 30min before this medication reduce the intensity of adverse effects.
• Frequent: Hypertension, tachycardia, nausea, vomiting, burning sensation of lips, inflammation of mucous membranes, sweating, cramps, and headache.
• Central Nervous System: CNS stimulation, headache, tingling, malaise.
• Gastrointestinal: Abdominal pain.
• Local: Pain and abscess.
• Eye And ENT: Increased tears, throat pain, eye pain, runny nose.
• Miscellaneous: Fever, sweating of the forehead, hands and other areas.
Avoid overdose, otherwise it may lead to extreme drowsiness.
Store at 20° to 25°C. Store it at controlled room temperature.
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